Differential Effects of a Long-Acting Angiotensin Converting Enzyme Inhibitor (Temocapril) and a Long-Acting Calcium Antagonist (Amlodipine) on Ventricular Ectopic Beats in Older Hypertensive Patients.

Abstract

We studied differences in the effects of a long-acting angiotensin-converting enzyme (ACE) inhibitor (temocapril) and a long-acting calcium channel blocker (amlodipine) on ventricular ectopic beats (VEB) in relation to sympathetic nerve activity in 46 patients with essential hypertension. We performed 24-h Holter electrocardiography and ambulatory blood pressure (BP) monitoring simultaneously, and examined blood samples during the baseline, temocapril and amlodipine treatment periods. The ambulatory BP was lower in the amlodipine period than in the temocapril period. However, the number of VEB was significantly increased in the amlodipine period compared to that in the baseline period (11.9 vs. 7.4/day, p 0.05). In the temocapril period, the number of VEB was not significantly increased compared to that in the baseline period (8.6 vs. 7.4/day, p 0.30). Ambulatory heart rate (HR) was significantly increased in the amlodipine

Effects of Strict Blood Pressure Control by a Long-Acting Calcium Channel Blocker on Brain Natriuretic Peptide and Urinary Albumin Excretion Rate in Japanese Hypertensive Patients

“…These results support those of our present study. SBP/DBP reductions were greater in the two prior studies (37,38) that observed pretreatment hypertensive patients than in the present study. The present study contributed the new finding that amlodipine treatment temporarily increased PR between baseline and 2 weeks.…”

“…In our previous study (37) we observed 46 hypertensive patients (mean age: 68 years; baseline SBP/DBP: 168/92 mmHg). In that study, the mean clinic SBP and DBP were reduced to 29 and 10 mmHg at 4 to 8 weeks of amlodipine treatment, and PR in the higher-dose group (8.6 mg mean) increased significantly.…”

Azelnidipine and Amlodipine: a Comparison of Their Pharmacokinetics and Effects on Ambulatory Blood Pressure.

“…The pulse rate during 24-h monitoring may reflect the diurnal condition of the patient more accurately than the office pulse rate. Mengden et al and Eguchi et al reported that the pulse rate increased significantly after amlodipine treatment in patients with hypertension (26,27), but the pulse rate was unchanged in many clinical trials with amlodipine (28,29). In the present study, differences in the baseline 24-h blood pressure values be- Other clinical studies of azelnidipine have also demonstrated that this drug does not increase the pulse rate (30,31).…”

Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: A scientific statement from the Asian Pacific Heart Association

“…We identified 11 eligible trials, including 6 trials conducted in China [11][12][13][14][15][16] and 5 in Japan; 17-21 2 had a cross-over design 17,20 and 9 had a parallel group design. [11][12][13][14][15][16]18,19,21 Characteristics of these trials are shown in Table 2.…”

“…The minimum luminal diameter of the coronary artery in all measured segments decreased significantly from baseline in the ACE Figure 1 Relation between the mean reduction and baseline level of daytime and nighttime systolic blood pressure by randomization group. The analysis included 10 calcium channel blocker (CCB) groups and 9 control groups from 9 trials, [11][12][13][14][15][16][17][18][19] respectively. Two trials were excluded, because daytime and nighttime blood pressures were not reported.…”