Differential effects of 5-hydroxytryptamine1A selective drugs on the 5-HT behavioral syndrome

Effects of Highly or Relatively Selective 5-HT1AReceptor Agonists on Lordosis in Female Rats

“…Furthermore, (+)8-OH-DPAT was most effective, because the dose of 0.25 mg/kg inhibited lordosis behavior. These results are in agreement with the reports that 8-OH-DPAT has a strong influence on the inhibition of lordosis, compared with BUS (Smith and Peroutka, 1986;Uphouse et al , 1992).…”

Anticonflict Action of Tandospirone in a Modified Geller-Seifter Conflict Test in Rats.

“…There are several reports showing that two azapirones, buspirone and ipsapirone, act as partial agonists with agonist activity predomi nating on 5-HT1A receptors (27)(28)(29). More over, Moser et al (30) have reported that a compound which acts primarily as an antago nist on 5-HT1A receptors showed anticonflict action.…”

An in vivo dialysis and behavioural study of the release of 5‐HT by p‐chloroamphetamine in reserpine‐treated rats

“…Some or all of these components can be elicited by drugs which selectively release neuro{'al 5-HT, such as p-chloroamphetamine (PCA; Trulson & Jacobs, 1976;Kuhn et al, 1985), as well as by agonists (Hjorth et al, 1982;Tricklebank et al, 1985a,b;Smith & Peroutka, 1986).…”

“…The 5-HT behavioural syndrome has usually been scored by methods based on rating scales for its components (Andrews et al, 1982;Tricklebank et al, 1985a,b;Smith & Peroutka, 1986) or by 'all or none' procedures (Trulson & Jacobs, 1976;Sloviter et al, 1978) which do not quantify either the intensity or the duration of each component. As Kuhn et al (1985) investigated the effect of reserpine pretreatment on the 5-HT syndrome elicited by PCA by an 'all or none' method, the interpretation of their findings is uncertain.…”