Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development

Abstract

The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats at different stages of development. Male Wistar rats were submitted to two different exercise protocols: a single session of treadmill (running 20 min) or a moderate daily exercise protocol (running 20 min for 2 weeks). Striata of rats aged 39 days postnatal (adolescents), 3 months (young adults), and 20 months (aged) were used. The single exercise session induced persistent effects on global HDAC activity only in the adolescent group, given that exercised rats showed decreased HDAC activity 1 and 18 h after training, without effect on histone H4 acetylation levels. However, the moderate daily exercise did not alter any histone acetylation marker in adolescent and mature groups in any time point evaluated after training. In sum, our data suggest that exercise impacts striatal HDAC activity in an age- and protocol-dependent manner. Specifically, this response seems to be more evident during the adolescent period and might suffer a molecular adaptation in response to chronic training.

Running-induced Functional Mobility Improvement in the Elderly Males is Driven by Enhanced Plasma BDNF Levels and the Modulation of Global Histone H4 Acetylation Status

“…On the other hand, a recent study (30) reported no difference in histone H4 acetylation levels between middle-aged runners and sedentary individuals. These findings were in agreement with the experimental studies reporting that histone acetylation status in response to exercise might act in an age-dependent manner (8,36).…”

Low-Intensity Exercise Routine for a Long Period of Time Prevents Osteosarcopenic Obesity in Sedentary Old Female Rats, by Decreasing Inflammation and Oxidative Stress and Increasing GDF-11

“…One of the main advantages of LIERLT is that it can be performed by all aging organisms, including those with obesity, lack of physical conditioning, and limited mobility. Different authors have recommended that exercise routines in rats over 18 months of age should not exceed 15 m/min, which is equivalent to a low-intensity exercise routine [52][53][54]. Performing exercise routines with speeds greater than 15 m/min can cause exhaustive exercise in old rats, which increases oxidative stress and damage to the skeletal muscle, heart, liver, lung, and kidney [55,56].…”

Intergenerational influence of paternal physical activity on the offspring’s brain: A systematic review and meta‐analysis

“…These environmental influences can be saved in the genome by alternative mechanisms through modulation of chromatin without modification in the DNA sequence (Baedke, 2013; Champroux et al., 2018; Goldberg et al., 2007; Jaenisch & Bird, 2003). On the contrary, experimental and clinical evidence in ever healthy or diseased individuals have documented that exercise plays a role as an important epigenetic modulator in many tissues, such as the brain, sperm, muscle, and leukocytes (Elsner et al., 2017; Fernandes et al., 2017; Lavratti et al., 2017). In addition, physical activity can alter the status of DNA methylation of the rat's brain.…”