Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic β-cell line, MIN6

Sawada, Fumi; Inoguchi, Toyoshi; Tsubouchi, Hirohito; Sasaki, Satoshi; Fujii, Masakazu; Maeda, Yasutaka; Morinaga, Hidetaka; Nomura, Masatoshi; Kobayashi, Kazuo; Takayanagi, Ryoichi

doi:10.1016/j.metabol.2008.01.038

Cited by 54 publications

(43 citation statements)

References 29 publications

(36 reference statements)

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“…Biologically, animal models have ruled out direct tumorigenic activity of glyburide and, conversely, supported an antiproliferative effect of all sulfonylureas (26)(27)(28)(29)(30). On the other hand, the current findings are consistent with an ROS-inducing effect that seems to pertain to glyburide (14) and not to other sulfonylureas, which in turn appear to exert a protective activity against ROS (31,32). Because it is well known that in diabetes chronic hyperglycemia can trigger cellular proliferation by generating ROS with subsequent intracellular signaling pathway impairment and DNA damage (33), this ROS scavenging effect of other sulfonylureas together with the oxidative stress induced by glyburide could explain the unbalanced risk of cancer we observed.…”

Section: Discussionsupporting

confidence: 75%

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The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes

Tuccori

Yin

et al. 2015

Diabetes Care

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OBJECTIVETo determine whether the use of glyburide is associated with an increased risk of cancer compared with the use of other second-generation sulfonylureas among patients with type 2 diabetes. RESEARCH DESIGN AND METHODSThe U.K. Clinical Practice Research Datalink was used to conduct a cohort study among 52,600 patients newly prescribed glyburide or other second-generation sulfonylureas between 1 January 1988 and 31 July 2013. A time-dependent Cox proportional hazards model was used to estimate adjusted hazard ratios (HRs) and 95% CIs of any cancer associated with the use of glyburide compared with the use of second-generation sulfonylureas. Secondary analyses were conducted to determine whether the association varied with cumulative duration of use and cumulative dose (expressed as defined daily dose [DDD]). RESULTSDuring 280,288 person-years of follow-up, 4,105 patients were given a new diagnosis of cancer (incidence rate 14.6 per 1,000 person-years). Overall, when compared with the use of other second-generation sulfonylureas, the use of glyburide was associated with a nonsignificant increased risk of any cancer

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Section: Discussionsupporting

confidence: 75%

“…These findings are supported by biological evidence, as glyburide seems to cause the production of reactive oxygen species (ROS), which is a well-known pro-oncogenic factor (14). In particular, this activity appears specific to glyburide and not to other sulfonylureas (15).…”

mentioning

confidence: 78%

The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes

Tuccori

Yin

et al. 2015

Diabetes Care

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“…This difference from tolbutamide may be due to the fact that gliclazide additionally acts as a free radical scavenger (68). Beneficial effects of gliclazide on survival of primary β cell and insulin-secreting cell lines have been reported in several recent papers (54,69,70). Administration of gliclazide represents a strategy to lower blood glucose concentration and additionally to delay diabetic complications such as micro-and macroangiopathies (71)(72)(73).…”

Section: Figurementioning

confidence: 99%

Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress

et al. 2009

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The enhanced oxidative stress associated with type 2 diabetes mellitus contributes to disease pathogenesis. We previously identified plasma membrane-associated ATP-sensitive K + (K ATP ) channels of pancreatic β cells as targets for oxidants. Here, we examined the effects of genetic and pharmacologic ablation of K ATP channels on loss of mouse β cell function and viability following oxidative stress. Using mice lacking the sulfonylurea receptor type 1 (Sur1) subunit of K ATP channels, we found that, compared with insulin secretion by WT islets, insulin secretion by Sur1 -/-islets was less susceptible to oxidative stress induced by the oxidant H 2 O 2 . This was likely, at least in part, a result of the reduced ability of H 2 O 2 to hyperpolarize plasma membrane potential and reduce cytosolic free Ca 2+ concentration ([Ca 2+ ] c ) in the Sur1 -/-β cells. Remarkably, Sur1 -/-β cells were less prone to apoptosis induced by H 2 O 2 or an NO donor than WT β cells, despite an enhanced basal rate of apoptosis. This protective effect was attributed to upregulation of the antioxidant enzymes SOD, glutathione peroxidase, and catalase. Upregulation of antioxidant enzymes and reduced sensitivity of Sur1 -/-cells to H 2 O 2 -induced apoptosis were mimicked by treatment with the sulfonylureas tolbutamide and gliclazide. Enzyme upregulation and protection against oxidant-induced apoptosis were abrogated by agents lowering [Ca 2+ ] c . Sur1 -/-mice were less susceptible than WT mice to streptozotocin-induced β cell destruction and subsequent hyperglycemia and death, which suggests that loss of K ATP channel activity may protect against streptozotocin-induced diabetes in vivo.

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“…Declining beta-cell function is the epitome phenomenon of worsening hyperglycemia over time [57] [61] [62]. SU's have been shown to expedite beta-cell failure and induce apoptosis at rates greater by two-to fourfold [63] [64]. It has been shown that maintaining glycemic control is difficult with SU over a period of time and up to 80% patients while on SU's will need insulin therapy, due to beta-cell exhaustion [57].…”

Section: Place In Therapymentioning

confidence: 99%

Teneligliptin: Heralding Change in Type 2 Diabetes

Maladkar¹,

Sankar²,

Kamat³

2016

JDM

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Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic β-cell line, MIN6

Cited by 54 publications

References 29 publications

The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes

The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes

Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress

Teneligliptin: Heralding Change in Type 2 Diabetes

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