Differential effect of polysaccharide and nonpolysaccharide components in Sijunzi decoction on spleen deficiency syndrome and their mechanisms

Ma, Ping; Peng, Ying; Zhao, Lijuan; Liu, Feng; Li, Xiaobo

doi:10.1016/j.phymed.2021.153790

Cited by 28 publications

(21 citation statements)

References 53 publications

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“…The most productive author was Duan Jin-ao, who had contributed to the field of TCM/GM and was a leading pioneer in the study of the relationship between GM and TCM, especially the research of TCM metabolomics ( Xiao et al., 2020 ; Zhang et al., 2021 ) and “eighteen incompatible medicaments” ( Yu et al., 2018 ; Yu et al., 2019 ), and was at the core of the collaborative relationship between authors. Li Xiao-bo from Shanghai Jiao Tong University mainly focused on the GM of spleen deficiency syndrome and the intervention mechanism of Sijunzi decoction ( Peng et al., 2020 ; Ma et al., 2021 ). Kim, Hojun from Dongguk University was mainly engaged in the research of TCM to improve obesity and metabolic syndrome by regulating GM ( Kim et al., 2014 ; Hussain et al., 2016 ), while Kim, Dong-hyun from Kyung Hee University was busy studying the role of TCM metabolites in the treatment of diseases such as colitis ( Kim et al., 2008 ; Jang et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

Yang

Hao

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundThere is a crosstalk between traditional Chinese medicine (TCM) and gut microbiota (GM), many articles have studied and discussed the relationship between the two. The purpose of this study is to use bibliometric analysis to explore the research status and development trends of the TCM/GM research, identify and analyze the highly cited papers relating to the TCM/GM.MethodsA literature search regarding TCM/GM publications from 2004 to 2021 was undertaken on August 13, 2022. The main information (full record and cited references) of publications was extracted from the Science Citation Index Expanded (SCI-E) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package, CiteSpace and VOSviewer were used for bibliometric analysis.ResultsA total of 830 papers were included. The publication years of papers were from 2004 to 2021. The number of papers had increased rapidly since 2018. China had the most publications and made most contributions to this field. Nanjing University of Chinese Medicine and Beijing University of Chinese Medicine were in the leading productive position in TCM/GM research, Chinese Academy of Chinese Medical Sciences had the highest total citations (TC). Duan Jin-ao from Nanjing University of Chinese Medicine had the largest number of publications, and Tong Xiao-lin from China Academy of Chinese Medical Sciences had the most TC. The Journal of Ethnopharmacology had the most published papers and the most TC. The main themes in TCM/GM included the role of GM in TCM treatment of glucolipid metabolism diseases and lower gastrointestinal diseases; the mechanism of interactions between GM and TCM to treat diseases; the links between TCM/GM and metabolism; and the relationship between GM and oral bioavailability of TCM.ConclusionThis study gained insight into the research status, hotspots and trends of global TCM/GM research, identified the most cited articles in TCM/GM and analyzed their characteristics, which may inform clinical researchers and practitioners’ future directions.

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Section: Discussionmentioning

confidence: 99%

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

Yang

Hao

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“…SDS has also been reported to be closely related to intestinal microbial disturbances, which refers to significant changes in the structure and composition of gut flora 1 , 10 , 11 , 28 , 36 . It has been reported that non-starch polysaccharides extracted from Codonopsis Radix , Radix Aconiti Lateralis Preparata and Sijunzi compound could regulate the structure and composition of intestinal flora and promote the reproduction of intestinal probiotics 3 , 5 , 37 . In present study, PHP not only have a positive effect on the diversity and abundance of probiotics, but also make the structure and composition of intestinal microorganisms close to those in the Ctrl group.…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats

Xiao

Zhao

Chang

et al. 2022

Sci Rep

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Pseudostellaria heterophylla, also called Tai-zi-shen (TZS) in Traditional Chinese Medicine (TCM), is always used clinically to treat spleen deficiency symptoms. Polysaccharides in TZS have various pharmacological activities, including anti-diabetic, immune regulation, and myocardial protection. However, the relationship between the spleen-invigorating effects of TZS or its polysaccharides and intestinal flora are not clear. This study investigated the effects of TZS decoction (PHD) and polysaccharide (PHP) on immune function and intestinal flora in a rat model of spleen deficiency syndrome (SDS) induced by a decoction of raw rhubarb (RRD). PHD and PHP increased immune organ index, alleviated inflammatory cell filtration, and reduced the levels of pro-inflammatory cytokines in rats with spleen deficiency syndrome. In addition, the production of butyric acid was promoted in PHD and PHP groups. Moreover, 16S rRNA gene sequencing showed that PHD and PHP reduced the relative abundance of Firmicutes while increasing the one of Bacteroidetes; significantly increased the abundance of Lactobacillus and decreased the abundance of Rombutsia; and PHP significantly increased the abundance of Alloprevotella. And there was a significant positive correlation between the alleviation of SDS and short-chain fatty acids (SCFAs)-producing bacteria. These findings suggested PHD and PHP, especially PHP, has a potential to relieve spleen deficiency by reducing intestinal inflammation, modulating structure and composition of gut microbiota, and promoting the production of butyric acid.

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“…Compared with monosaccharides, compounded polysaccharides can combine the biological activities of each monosaccharide and play a synergistic effect. In most cases, polysaccharides are absorbed as oligosaccharides, which directly or indirectly affect intestinal flora to influence efficacy ( Ma et al, 2021a ), proteins are mostly absorbed as oligopeptides to exert their functions, miRNAs can be absorbed through the gastrointestinal tract and can act as intercellular inhibitory signaling molecules in target tissues ( Zhang et al, 2020b ). Hence, the study of biomolecules should be different from that of small molecules in terms of approach and strategy.…”

Section: Shortcomings Of Pharmacodynamic Substances Study In Chinese ...mentioning

confidence: 99%

Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances

Lin

Wang

et al. 2022

Arabian Journal of Chemistry

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Differential effect of polysaccharide and nonpolysaccharide components in Sijunzi decoction on spleen deficiency syndrome and their mechanisms

Cited by 28 publications

References 53 publications

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

The interactions between traditional Chinese medicine and gut microbiota: Global research status and trends

Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats

Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances

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