Differential Effect of Growth Factors on Intestinal Wall Components

Regulation of intestinal regeneration: New insights

“…While only regeneration of muscularis mucosa has been identified in the serosal patch model, there are adaptive changes in the muscularis of the adjacent intestine (Thompson, 1996). EGF blunts this adaptive response while stimulating mucosal growth.…”

Heparin-Binding Epidermal Growth Factor-Like Growth Factor Protects Rat Intestine from Ischemia/Reperfusion Injury

“…Subsequent reperfusion leads to continued destruction of the villus structures [3,4], in part due to the generation of toxic oxygen free radicals [5]. Epithelial cell proliferation and migration (restitution) reduce the extent of this damage [6]. Both proliferation and restitution require the presence of multiple substances including growth factors, cytokines, and hormones, which serve to mediate the inflammatory response and to stimulate recovery of the injured intestine [6 -10].…”

Role of Integrins in Enterocyte Migration

“…A wide variety of growth factors are likely to be released during mucosal injury 35 , 36 and synthesized during mucosal repair 37 –41 . These are likely to modulate not only cell proliferation, 10 , 42 –45 but also restitutive cell motility 5 , 6 , 10 and tissue/organ repair processes, including angiogenesis, 46 innervation 47 and remodelling 4 . Evidence from a wide variety of cell types suggests that, in addition to their direct effects, these growth factors are also likely to modulate matrix synthesis and proteolysis 48 –54…”