Differential effect of chronic stress on mouse hippocampal memory and affective behavior: Role of major ovarian hormones

Karisetty, Bhanu Chandra; Maitra, Swati; Wahul, Abhipradnya Bipin; Musalamadugu, Anusha; Khandelwal, Nitin; Guntupalli, Sumasri; Garikapati, Ramya; Jhansyrani, Thatiparthi; Kumar, Arvind; Chakravarty, Sumana

doi:10.1016/j.bbr.2016.10.034

Cited by 25 publications

(7 citation statements)

References 45 publications

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“…The successful preparation of the perimenopausal emotional disorder animal model is the essential condition to simulate the clinical patient symptoms and manifestations, thus investigating its etiology, pathogenesis, and developing drugs [42]. Perimenopausal emotional disorder is associated with physiological specificity and pathological complexity; as a result, the construction of animal model of this disease in scientific research is partially different from the simple emotional disorder (depression or anxiety).…”

Section: Discussionmentioning

confidence: 99%

Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression

Yang

et al. 2020

BioMed Research International

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Perimenopausal women are associated with increased risks of depression and anxiety, which may be potentially related to the lack of ovarian hormone with antidepression activity in the body. However, the precise mechanism remains unclear so far. This study first adopted the Sprague-Dawley (SD) female rats to construct the ovariectomy (OVX) combined with a chronic unpredictable stress (CUS) model. Then, a series of behavioral experimental results revealed that the ovariectomized rats receiving CUS had remarkably elevated anxiety and depression behaviors relative to those in sham group rats, and the sucrose preference rate in the sucrose preference test (SPT) was evidently reduced. In elevated plus maze test (EPM) experiment, the open arm entry time and open arm duration were decreased. In the open field test (OFT), the number of line crossings, rearing number, center square entries, and center square duration were reduced; the grooming time was extended; and the number of fecal particles in rats was increased. In the forced swimming test (FST), the rat immobility rate was increased, while the numbers of swimming and crawling were decreased. Afterwards, we discovered that OVX downregulated the serum levels of estradiol and corticosterone in rats. Thereafter, IF results suggested that OVX dramatically induced the increasing of the number of activated microglial cells in prefrontal cortices and the level of M1-type marker iNOS. Finally, PCR results demonstrated that, compared with the sham group, the proinflammatory and prooxidative genes, such as IL-1β, IL-6, TNF-α, iNOS, and CX3CR1, were upregulated in the prefrontal cortices of OVX rats after CUS stimulation, whereas the anti-inflammatory factor Arg1 and microglial cell negative regulatory factor CD200 were downregulated. To sum up, OVX enhances the CUS-mediated anxiety and depression phenomena in rats, and its mechanism may be related to inducing the activation and polarization of microglial cells in the prefrontal cortex of animal and to accelerating the inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression

Yang

et al. 2020

BioMed Research International

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“…NMDARs, especially GluN2A- and GluN2B-containing, are essential for regulating neuronal plasticity [ 128 ]. Molecular analysis in the hippocampus of female mice showed an increase in the expression of Grin2A and Grin2B genes after CUS and after administration of two hormonal compounds (estradiol, progesterone) [ 131 ]. Reports suggest estrogens’ role in structural and functional synaptic plasticity and long-term potentiation (LTP) in the hippocampus [ 131 ].…”

Section: Alterations In Postsynaptic Density Proteins In Depressive D...mentioning

confidence: 99%

Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders

Samojedny

Czechowska

Pańczyszyn-Trzewik

et al. 2022

IJMS

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Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of these conditions. In recent years, there has been growing interest in the role of the glutamatergic system in the context of pharmacotherapy of DDs. Thus, it has become increasingly important to explore the functioning of excitatory synapses in pathogenesis and pharmacological treatment of psychiatric disorders (including DDs). This knowledge may lead to the description of new mechanisms of depression and indicate new potential targets for the pharmacotherapy of illness. An excitatory synapse is a highly complex and very dynamic structure, containing a vast number of proteins. This review aimed to discuss in detail the role of the key postsynaptic proteins (e.g., NMDAR, AMPAR, mGluR5, PSD-95, Homer, NOS etc.) in the excitatory synapse and to systematize the knowledge about changes that occur in the clinical course of depression and after antidepressant treatment. In addition, a discussion on the potential use of ligands and/or modulators of postsynaptic proteins at the excitatory synapse has been presented.

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“…Chronic stress can affect the body's physiological and mental health, including its metabolic and immune systems. It is one of the risk factors for anxiety, depression, cardiovascular disease, and other diseases (McEwen, 2008;Karisetty et al, 2017). Due to anatomical and physiological structures, women in the reproductive age are more susceptible than men to developing stress-related psychiatric disorders such as depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model

Lin

Gong

et al. 2020

Front. Pharmacol.

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Background: Chronic stress has been known to impair the female reproductive function, but the mechanism remains to be further investigated. Chaiyu-Dixian Formula (CYDXF) has been reported to regulate human endocrine disorders clinically. However, whether this formula can affect chronic stress-induced ovarian follicular development is not clear. Aim of the study:To examine effects of CYDXF on follicular development and explore possible mech anisms in a chronic unpredictable mild stress (CUMS) model.Materials and Methods: Adult female rats were randomly divided into 5 groups control group, CUMS group (saline treatment), CUMS+Estradiol (E 2 ) (0.1 mg/kg) group, CUMS +CYDXF (2.73 g/kg) group, and CUMS+CYDXF (5.46 g/kg) group. Body weights and behavioral tests were documented. Serum hormone levels were determined by enzymelinked immunosorbent assay (ELISA). Western blotting was used to detect the protein levels in the PI3K/Akt pathway and brain-derived neurotrophic factor (BDNF). The follicles were analyzed and classified according to their morphological characterization.Results: CYDXF relieved depression-like behaviors and ameliorated the abnormality in rat estrous cycle within the rat model of CUMS. Moreover, CYDXF could regulate endocrine disorders, increase the proportion of antral follicles as well as decrease the proportion of follicular atresia, which suggested that CYDXF could alleviate abnormal follicular development and improve overall ovarian function. Furthermore, CYDXF also activated the BDNF-mediated PI3K/Akt signaling pathway.Conclusions: CYDXF (at dose of both 2.73 and 5.46 g/kg) attenuated chronic stressinduced abnormal ovarian follicular development by relieving depression-like behaviors and improving ovarian function through partly the regulation of the BDNF-mediated PI3K/ Akt pathway.

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Differential effect of chronic stress on mouse hippocampal memory and affective behavior: Role of major ovarian hormones

Cited by 25 publications

References 45 publications

Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression

Ovariectomy Induces Microglial Cell Activation and Inflammatory Response in Rat Prefrontal Cortices to Accelerate the Chronic Unpredictable Stress-Mediated Anxiety and Depression

Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders

Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model

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