Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation
Matthieu Glorion,
Florentina Pascale,
Maxime Huriet
et al.
Abstract:IntroductionLung transplantation often results in primary and/or chronic dysfunctions that are related to early perioperative innate allo-responses where myeloid subsets play a major role. Corticosteroids are administered upon surgery as a standard-of-care but their action on the different myeloid cell subsets in that context is not known.MethodsTo address this issue, we used a cross-circulatory platform perfusing an extracorporeal lung coupled to cell mapping in the pig model, that enabled us to study the rec… Show more
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