“…DDM is a simple yet powerful tool to analyze time-lapse microscopy experiments and extract quantitative information about the structure and dynamics of a large class of microscope samples. As of today, DDM was applied successfully to a wide variety of physical and biological systems [7], including dilute isotropic [6,22] and anisotropic [23,24] colloidal particles, dense colloidal suspensions [12,25,26], molecular [27] and complex [28,29] fluids, motile microorganisms [12,30,31], sub-cellular structures [32,33], and microrheology [34,35]. DDM offers numerous advantages [9], such a simple implementation based on optical microscopes, low sensitivity to normal amounts of dirt or multiple scattering, and the possibility of using a variety of image-contrast mechanisms: bright field [6], dark-field [22], phase contrast [30], wide field fluorescence [36], polarized [24,29], differential interference contrast [32], light sheet [37], and confocal microscopy (ConDDM) [12,25,26,38].…”