Abstract:Various host and parasite factors interact to determine the outcome of
infection. We investigated the effects of initial infectious dose and
co-infection with a red blood cell-limiting helminth on the within-host
dynamics of murine malaria. Using a time-series approach to model the
within-host “epidemiology” of malaria, we found that increasing
initial dose reduced time to peak cell-to-cell parasite propagation, but
also reduced its magnitude, while helminth co-infection delayed peak
malaria propagation, excep… Show more
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