Differential distribution of Trypanosoma cruzi clones in human chronic chagasic cardiopathic and non-cardiopathic individuals

Genotyping of Trypanosoma cruzi Sublineage in Human Samples from a North-East Argentina Area by Hybridization with DNA Probes and Specific Polymerase Chain Reaction (PCR)

“…In that context, a correlation between clinical manifestation and the genotypes could be hypothesized as the cardiac sign that Chagas disease is predominant in Santa Fe province and in all of the country of Argentina. [47][48][49][50] This hypothesis would be supported by the correlation of cardiac signs with TcII strains described by other authors, 51,52 even though more evidences of this assumption should be obtained.…”

Therapy, diagnosis and prognosis of chronic Chagas disease: insight gained in Argentina

“…These results are consistent with the hypothesis of a gradual clonal exhaustion in the CD8 + T cell population, perhaps as a result of continuous antigenic stimulation by persistent parasites (Albareda et al 2006). On the other hand, the specific response has also been shown to select for sublineage clones of T. cruzi leading to the development of chagasic cardiomyopathy (Venegas et al 2009). Several studies have revealed a positive association between tissue parasitism and the severity of inflammation.…”

Molecular Epidemiology of Parasitic Diseases: The Chagas Disease Model

“…Moreover, some authors have shown that the T. cruzi population in a patient's bloodstream could be dissimilar to the parasite population that causes tissue damage (Vago et al, 2000). Differences were found in T. cruzi populations in the bloodstreams of patients with chronic Chagasic cardiomyopathy and those of Chagasic patients without cardiomyopathy (Venegas et al, 2009). Microsatellite analyses have also shown multiclonality in heart samples and in the bloodstreams of infected patients, demonstrating that specific populations of T. cruzi can probably determine disease outcome (Burgos et al, 2007;Valadares et al, 2008).…”