Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy

Sindram-Trujillo, Aliana P; Scherjon, Sicco A.; Miert, Paula P. van; Schip, Jolien J van; Kanhai, Humphrey H.H.; Roelen, Dave L.; Claas, Frans H.J.

doi:10.1016/s0198-8859(03)00170-8

Cited by 55 publications

(36 citation statements)

References 46 publications

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“…In pregnancies with FGR, with or without PE, we also detected a significant correlation between NK cell proportion and trophoblast infiltration. Our in vivo data support the hypothesized central role of NK cells in regulating trophoblast invasion [33,36,38], and the reduced NK cell proportions found among cases, especially in FGR pregnancies, suggest that reduced proportions of NK cells may be part of the impaired placental development and pathogenesis of the disease.…”

Section: Discussionsupporting

confidence: 82%

Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis

et al. 2005

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Extravillous trophoblasts are major participants in placental development and remodelling of spiral arteries. Trophoblast invasion is regulated by maternal immune cells, and abnormal leucocyte subpopulation composition has been reported in implantation failure. In pre-eclampsia (PE), with or without foetal growth restriction (FGR), superficial trophoblast invasion and insufficient remodelling of spiral arteries are common findings. In the present study, we have compared spiral artery remodelling and leucocyte composition in decidual tissue from 30 cases (PE=8, FGR=5, PE + FGR=17) and 31 controls. Six histological remodelling criteria were established, and each pregnancy obtained a remodelling score. Numbers of natural killer (NK) cells (CD56+), T cells (CD3+) and activated (CD25+ or CD69+) leucocytes were determined and related to total leucocyte (CD45+) numbers in serial sections. Cases demonstrated significantly impaired spiral artery remodelling, inappropriate placental growth and reduced NK cell proportions, as compared to controls (P=0.02, P<0.001 and P=0.01, respectively). Reduced NK cell proportion was primarily found in pregnancies complicated by FGR, with or without PE, and a significant positive correlation was observed between NK cell proportion, trophoblast infiltration and placental growth. Our in vivo observations support the hypothesized association between NK cells, impaired placental development and pathogenesis of PE/FGR.

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Section: Discussionsupporting

confidence: 82%

Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis

et al. 2005

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“…Results between different groups have been inconsistent. Sindram-Trujillo et al (2003) reported increased numbers of CD56-positive CD16-negative uNK cells in decidua parietalis compared with decidua basalis at term. In contrast, others have suggested that the close association between uNK cells and extravillous trophoblast supports a role in the control of trophoblast invasion (Kusumi et al, 2006).…”

Section: Distribution Of Uterine Nk Cellsmentioning

confidence: 93%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

314

280

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“…At the same time research has also revealed protective effects for the mother that include reducing the risks of infections and cardiac disease [11,14]. Finally, the pregnant woman does not reject the fetus as foreign tissue in part due to the fetal cells within her tissues that tolerize her immune system [20]. Given these findings, we propose that both the couple and their surrogate candidate be informed about the medical risks associated with maternal-fetal cell exchange.…”

Section: New Medical Advances In Pregnancymentioning

confidence: 98%

New Ethical Horizons in Gestational Surrogacy

Loike¹,

Fischbach²

2013

J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol

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Gestational surrogacy occurs when a woman allows a 4-7 day embryo that was not generated from her own egg to develop in her uterus. In this paper, we review emerging scientific evidence to show how maternal-fetal cell exchange (microchimerism) may affect the future health of both surrogate and fetus/child. In light of these findings, we propose that four aspects of gestational surrogacy be examined: (1) the medical health and psychological outcomes of maternal-fetal cell exchange in surrogacy, (2) surrogacy laws and contractual agreements between the various parties, (3) provisions of a more comprehensive genetic family history and genetic screening from all parties involved, and (4) appreciation of the ethical and social complexities of surrogacy. We support gestational surrogacy provided that there is comprehensive informed consent. To be comprehensive, consent should include our current understanding of microchimerism with respect to the medical, legal, genetic, and ethical elements of surrogacy.

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Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy

Cited by 55 publications

References 46 publications

Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis

Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis

Immune cells in the placental bed

New Ethical Horizons in Gestational Surrogacy

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