Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

Gehlert, Donald R.; Gackenheimer, Susan L.

doi:10.1016/s0306-4522(96)00340-5

Cited by 52 publications

(40 citation statements)

References 32 publications

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“…Recent studies (1,23) suggest that PYY(3-36) may act, in part, through control of vagal signaling to the brain. On the other hand, high-affinity PYY(3-36) binding sites are located throughout the brain in regions with and without a blood-brain barrier (13,18). It is not clear whether the source of endogenous ligand for these receptors is in the brain or periphery.…”

Section: Discussionmentioning

confidence: 99%

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Chelikani

Haver²,

Reeve³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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reduces food intake and weight gain in rats when injected into the peritoneal cavity twice daily for 7 days. Numerous laboratories have failed to confirm that daily injections of PYY(3-36) decrease body weight. Continuous subcutaneous administration of PYY(3-36) by osmotic minipump has been reported to reduce daily food intake in rodents but only during the first 3-4 days of administration. Here we show the effects of different daily patterns of intravenous infusion of PYY(3-36) on food intake, body weight, and adiposity in rats tethered via infusion swivels to computercontrolled pumps. Measurement of food bowl weight recorded by computer every 20 s permitted daily assessment of the instantaneous effects of PYY(3-36) administration on food intake and meal patterns. One-hour intravenous infusions of PYY(3-36) at 30 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 every other hour for 10 days produced a sustained reduction in daily food intake of ϳ20% and decreased body weight and adiposity by 7 and 35%, respectively. Thus dosage pattern is critical for producing a sustained effect of PYY(3-36) on food intake and adiposity.gastrointestinal; body weight; body composition THE GASTROINTESTINAL SYSTEM plays an important sensing and signaling role in control of food intake and regulation of energy reserves (5). A growing number of peptide signals of gastric, intestinal, and pancreatic origin have been shown to inhibit short-term food intake when administered acutely to experimental animals and humans. These include cholecystokinin, amylin, glucagon-like peptide-1 (GLP-1), oxyntomodulin, peptide YY(3-36) ], pancreatic polypeptide, gastrinreleasing peptides (GRPs) GRP-27 and GRP-

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Section: Discussionmentioning

confidence: 99%

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Chelikani

Haver²,

Reeve³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Here, we have shown that NPY stimulates feeding behaviour also in guinea-pigs. Even if there are species di erences in the level of expression and distribution of the NPY receptor subtypes in the brain (Dumont et al, 1998;Gehlert & Gackenheimer, 1997), and in the binding characteristics of the cloned receptors Eriksson et al, 1998;StarbaÈ ck et al, 2000), NPY and its analogues, as well as the Y 1 and Y 5 antagonists, seemed to behave in a similar manner in guinea-pigs as reported earlier for rats (Haynes et al, 1998;Polidori et al, 2000;Wieland et al, 1998). Our results favour the hypothesis that both Y 1 and Y 5 receptors mediate NPY-induced food intake.…”

Section: British Journal Of Pharmacology Vol 135 (8)mentioning

confidence: 99%

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Lecklin

Lundell

Paananen

et al. 2002

British J Pharmacology

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1 Neuropeptide Y (NPY) is one of the most potent stimulants of food intake. It has been debated which receptor subtype mediates this response. Initially Y 1 was proposed, but later Y 5 was announced as a`feeding' receptor in rats and mice. Very little is known regarding other mammals. The present study attempts to characterize the role of NPY in feeding behaviour in the distantly related guinea-pig. When infused intracerebroventricularly, NPY dose-dependently increased food intake. 2 PYY, (Leu 31 ,Pro 34 )NPY and NPY(2 ± 36) stimulated feeding, whereas NPY(13 ± 36) had no e ect. These data suggest that either Y 1 or Y 5 receptors or both may mediate NPY induced food intake in guinea-pigs. 3 The Y 1 receptor antagonists, BIBO 3304 and H 409/22 displayed nanomolar a nity for the Y 1 receptor (K i values 1.1+0.2 nM and 5.6+0.9 nM, respectively), but low a nity for the Y 2 or Y 5 receptors. When guinea-pigs were pretreated with BIBO 3304 and H 409/22, the response to NPY was inhibited. 4 The Y 5 antagonist, CGP 71683A had high a nity for the Y 5 receptor (K i 1.3+0.05 nM) without having any signi®cant activities at the Y 1 and Y 2 receptors. When CGP 71683A was infused into brain ventricles, the feeding response to NPY was attenuated. 5 The present study shows that NPY stimulates feeding in guinea-pigs through Y 1 and Y 5 receptors. As the guinea-pig is very distantly related to the rat and mouse, this suggests that both Y 1 and Y 5 receptors may mediate NPY-induced hyperphagia also in other orders of mammals.

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“…Özel otoradyografik reseptör çalışmaları reseptöre özgül ligand kullanarak kemirgenlerde NPY'nin farklı alt tipleri için özgül bölgeleri ortaya koyan bir profil çıkarılmıştır. [22][23][24][25] Örneğin çalışmaların çoğunda kortekste, amigdalada ve beyin sapında yüksek NPY1R reseptör ekspresyonu bildirilmiştir. NPY2R ise hipokampus, beyin sapı ve septumda yüksek dağılıma sahiptir.…”

Section: Vulnerabilite (Zedelenebilirlik) Ve Esneklikunclassified

Neuropeptide Y and Stress

Gülsün¹,

Tamam²

2012

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETStres ve bireysel baş etme yetilerinin nörobiyolojik yönü birçok araştırmacının ilgi odağı olmuştur. Bir dizi çalışmada genetik değişkenler ile strese tepki düzeyleri ve yaşam olayları arasında bir ilişki olduğu gösterilmiştir. Nöropeptid Y stres esnekliğini düzenleyen sistemlerden biridir. Uzun süreli ya da tekrarlayan stres durumlarında nöropeptid Y beynin anahtar bölgelerinden salınır. Bu sistem stresle ilgili bozukluklara yatkınlığı farklı kişilerde farklı esneklikte işleyiş gösterir. Gen-çevre etkileşimleri için özellikle ilgi çekici olan strese duyarlı sinyal moleküllerini kodlayan genlerin değişimidir. Bu durum strese yatkınlığa ya da esnekliğe katkıda bulunabilir. Nöropeptid Y sistemi de strese davranışsal uyumda anahtar rol oynamaktadır. Nöropeptid Y düzeyinin azalmış olması tedaviye dirençli depresyonda ve travma sonrası stres bozukluğunda da gözlenmiştir. Düşük nöropeptid Y ekspresyonunun ya da strese yanıt olarak nöropeptid Y sisteminin yeterince işlevsel olmaması ve sonucunda ortaya çıkan stres esnekliğinin az olması stresle ilişkili bozukluklara yatkınlığı arttırabilmektedir. Anahtar Sözcükler: Nöropeptid Y, stres, stres esnekliği ABSTRACTThe neurobiological aspects of stress and coping skills has been the focus of interest for many researchers. Some of the studies has shown that there is a significant relationship among genetically variables, stress response and life events. Neuropeptide Y is one of the systems regulating the stress response. Under the prolonged or repeated trauma neuropeptide Y is released from the brain's key areas. This system shows different levels of functioning in individuals with different levels of resilience. There is particular interest in the variations of genes that encode stress-sensitive signaling molecules during geneenvironment interaction. This condition may contribute to susceptibility of stress or stress resilience. Neuropeptide Y system plays a key role in the adaptation to behavioral stress. The reduced levels of neuropeptide Y have also been observed in treatment-resistant depression and posttraumatic stress disorder. Lower level of neuropeptide Y expression and dysfunctional neuro-

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Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

Cited by 52 publications

References 32 publications

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Neuropeptide Y and Stress

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Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

Cited by 52 publications

References 32 publications

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig

Neuropeptide Y and Stress

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Product

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Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig