Differential distribution of nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the superficial and deep muscle layers of the dorsum of the rat

Tsukagoshi, Midori; Funakoshi, Kengo; Goris, Richard C.; Kishida, Reiji

doi:10.1016/s0361-9230(02)00814-6

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…+ positive, À negative cle surface area) between the layers of the skeletal muscles. In the dorsal muscles, the density of CGRP+ varicosities in the trapezius muscle is eight times higher than that in the longissimus muscle (Tsukagoshi et al 2002). The present results indicated that the percentage of CGRP+ neurons among total neurons projecting to the trapezius muscle was more than 50% higher than the percentage of CGRP+ neurons projecting to the longissimus muscle.…”

Section: Distribution Of Cgrp Positive Neurons Projecting To the Dorscontrasting

confidence: 47%

“…In the dorsum of the rat, there is a differential distribution of CGRP positive (CGRP+) nerve fibers between the superficial muscle layer and the deeper muscle layer. The density of CGRP+ varicosities in the superficial muscles is more than ten times greater than in the deep muscles, suggesting a functional difference between the superficial muscles and deep muscles (Tsukagoshi et al 2002).…”

Section: Introductionmentioning

confidence: 86%

“…The differential co-localization percentage might be due to the differential transport of CGRP to the peripheral targets. Thus, the CGRP+ nerve fibers in the trapezius muscle have a higher percentage of co-localization with TRPV1, as well as a higher varicosity density (Tsukagoshi et al 2002).…”

Section: Co-localization Of Cgrp and Trpv1 In The Sensory Neurons Andmentioning

confidence: 94%

“…CGRP-and SP-immunoreactive varicose nerve fibers in the skin were found along the blood vessel walls, and in the dermal and hypodermal layers as free nerve endings. In skeletal muscles, on the other hand, neuropeptide-positive varicose fibers are found predominantly along the blood vessel walls, as well as in the nerve trunk (Tsukagoshi et al 2002). In the dorsum of the rat, there is a differential distribution of CGRP positive (CGRP+) nerve fibers between the superficial muscle layer and the deeper muscle layer.…”

Section: Introductionmentioning

confidence: 99%

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Differential distribution of vanilloid receptors in the primary sensory neurons projecting to the dorsal skin and muscles

Tsukagoshi

Goris

Funakoshi

2006

Histochem Cell Biol

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We examined transient receptor potential (TRP) V1 and TRPV2 expression in calcitonin gene-related peptide (CGRP) positive (+) primary sensory neurons projecting to the skin and skeletal muscles of the rat dorsum. Among the dorsal root ganglia at the levels from C2 to Th1, 34.9% of neurons projecting to the skin were positive for CGRP, and 32.6% or 21.6% of neurons projecting to the trapezius muscle or the longissimus muscle were positive for CGRP. Of the small CGRP+ neurons projecting to the skin, 53.5% were positive for TRPV1, 11.6% were positive for TRPV2. Of the small CGRP+ neurons projecting to the trapezius or the longissimus, 53.1 or 53.2% were positive for TRPV1, 8.8 or 8.3% were positive for TRPV2, respectively. In the periphery, 29.3% of CGRP+ nerve fibers were positive for TRPV1 in the skin, whereas 65.0 or 59.8% were positive in the trapezius or the longissimus. Therefore, the present study showed that the percentage of CGRP+ neurons projecting to the trapezius is higher than that to the longissimus, and that the co-localization percentage of CGRP and TRPV1 on the sensory nerves was also higher in the trapezius than in the longissimus and the skin.

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Section: Distribution Of Cgrp Positive Neurons Projecting To the Dorscontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 86%

Section: Co-localization Of Cgrp and Trpv1 In The Sensory Neurons Andmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differential distribution of vanilloid receptors in the primary sensory neurons projecting to the dorsal skin and muscles

Tsukagoshi

Goris

Funakoshi

2006

Histochem Cell Biol

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“…In rat skeletal muscle, SP-IR and CGRP-IR NFs are more often found along blood vessels in the superficial muscle layers than in deep layers [22]. The different distribution and insertion of SP-IR and CGRP-IR NFs may be related to functional properties associated with blood supply for the muscle.…”

Section: Discussionmentioning

confidence: 99%

Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle

Yamazaki

Sato

2013

Eur Arch Otorhinolaryngol

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Substance P-immunoreactive nerve fiber (SP-IR NF) and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation and blood supply. SP-IR and CGRP-IR NFs in the tensor tympani muscle (TTM) of the human middle ear have yet to be described. In this study, the TTM, tympanic membrane, malleus in the middle ear and tensor veli palatini muscle (TVPM) were examined by whole-mount immunohistochemistry in tissue from Japanese subjects. Thirteen human cadavers (ranging in age from 46 to 90 years) were used in this study. SP-IR and CGRP-IR NFs were primarily found on vessels at the origin, insertion and belly of the surface of the TTM and on the internal surface of the tympanic membrane. These neural factors were also detected on the surface of the malleus and the insertion of the TVPM. Therefore, our results indicate that existence of the SP-IR and CGRP-IR NFs of the TTM and the TVPM may reflect muscle properties involved in pain or inflammation of the middle ear.

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A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas

et al. 2006

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Differential distribution of nerve fibers immunoreactive for substance P and calcitonin gene-related peptide in the superficial and deep muscle layers of the dorsum of the rat

Cited by 9 publications

References 14 publications

Differential distribution of vanilloid receptors in the primary sensory neurons projecting to the dorsal skin and muscles

Differential distribution of vanilloid receptors in the primary sensory neurons projecting to the dorsal skin and muscles

Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle

A quantitative analysis of the sensory and sympathetic innervation of the mouse pancreas

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