Differential Distribution of microRNAs in Breast Cancer Grouped by Clinicopathological Subtypes

Li, Jianyi; Song, Jia; Zhang, Wenhai; Zhang, Yang; Kang, Yuan; Li, Pi-Song

doi:10.7314/apjcp.2013.14.5.3197

Cited by 27 publications

(19 citation statements)

References 16 publications

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“…The miR-204-3p has been found to be deregulated in several tumors, such as hepatocellular carcinoma, glioma, and breast cancer (40)(41)(42), and is closely related with ccRCC and upper tract urothelial carcinomas (43). In our study, we found that circATP2B1 functions as the reservoir of miR-204-3p, by stabilizing or promoting the transcription of miR-204-3p to inhibit ccRCC invasion.…”

Section: Discussionsupporting

confidence: 54%

ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma

et al. 2018

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Early studies have indicated that estrogen receptor beta (ERβ) can influence the progression of clear cell renal cell carcinoma (ccRCC). Here, we report the mechanistic details of ERβ-mediated progression of ccRCC. ERβ increased ccRCC cell invasion via suppression of circular RNA ATP2B1 (circATP2B1) expression by binding directly to the 5' promoter region of its host gene ATPase plasma membrane Ca2 transporting 1 (ATP2B1). ERβ-suppressed circATP2B1 then led to reduced miR-204-3p, which increased fibronectin 1 (FN1) expression and enhanced ccRCC cell invasion. Targeting ERβ with shRNA suppressed ccRCC metastasis in a murine model of RCC; adding circATP2B1 shRNA partly reversed this effect. Consistent with these experimental results, ccRCC patient survival data from The Cancer Genome Atlas indicated that a patient with higher ERβ and FN1 expression had worse overall survival and a patient with higher miR-204-3p expression had significantly better overall survival. Together, these results suggest that ERβ promotes ccRCC cell invasion by altering the ERβ/circATP2B1/miR-204-3p/FN1 axis and that therapeutic targeting of this newly identified pathway may better prevent ccRCC progression. These results identify an ERβ/circATP2B1/miR-204-3p/FN1 signaling axis in RCC, suggesting ERβ and circular RNA ATP2B1 as prognostic biomarkers for this disease. .

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Section: Discussionsupporting

confidence: 54%

ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma

et al. 2018

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“…The expression of four of the observed DE miRNAs (miR-142-5p, miR-150-5p, miR-320a, and miR-4433b-5p) selected were further validated by RT-qPCR (test phase) in a larger number of samples. These miRNAs have been previously characterized by their oncogenic and/or tumor suppressor function in other types of cancers, including BC [29,45,46], except for miR-4433-5p, that is a new miRNA with no description in cancer so far.…”

Section: Discussionmentioning

confidence: 99%

Identification of miRNAs Enriched in Extracellular Vesicles Derived from Serum Samples of Breast Cancer Patients

et al. 2020

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MicroRNAs derived from extracellular vesicles (EV-miRNAs) are circulating miRNAs considered as potential new diagnostic markers for cancer that can be easily detected in liquid biopsies. In this study, we performed RNA sequencing analysis as a screening strategy to identify EV-miRNAs derived from serum of clinically well-annotated breast cancer (BC) patients from the south of Brazil. EVs from three groups of samples (healthy controls (CT), luminal A (LA), and triple-negative (TNBC)) were isolated from serum using a precipitation method and analyzed by RNA-seq (screening phase). Subsequently, four EV-miRNAs (miR-142-5p, miR-150-5p, miR-320a, and miR-4433b-5p) were selected to be quantified by quantitative real-time PCR (RT-qPCR) in individual samples (test phase). A panel composed of miR-142-5p, miR-320a, and miR-4433b-5p distinguished BC patients from CT with an area under the curve (AUC) of 0.8387 (93.33% sensitivity, 68.75% specificity). The combination of miR-142-5p and miR-320a distinguished LA patients from CT with an AUC of 0.9410 (100% sensitivity, 93.80% specificity). Interestingly, decreased expression of miR-142-5p and miR-150-5p were significantly associated with more advanced tumor grades (grade III), while the decreased expression of miR-142-5p and miR-320a was associated with a larger tumor size. These results provide insights into the potential application of EVs-miRNAs from serum as novel specific markers for early diagnosis of BC.

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“…Recently dysregulated miRNAs have been reported that associated with every aspect of breast tumor biology, including tumor progression (Li et al, 2013a), apoptosis (Anaya-Ruiz et al, 2013), different distribution in clinicopathological subtypes (Li et al, 2013b), and acquisition of resistance to various chemotherapeutic agents. Causes of anti-cancer drug resistance are believed to be complex and current studies have indicated that the acquisition of chemotherapy drug resistance may also be modulated via the changes in miRNA levels.…”

Section: Discussionmentioning

confidence: 99%

Down-regulation of miRNA-452 is Associated with Adriamycin-resistance in Breast Cancer Cells

Gong²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Differential Distribution of microRNAs in Breast Cancer Grouped by Clinicopathological Subtypes

Cited by 27 publications

References 16 publications

ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma

ERβ-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma

Identification of miRNAs Enriched in Extracellular Vesicles Derived from Serum Samples of Breast Cancer Patients

Down-regulation of miRNA-452 is Associated with Adriamycin-resistance in Breast Cancer Cells

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