Differential distribution of insulin-like growth factors and their binding proteins within bone: Relationship to bone mineral density

Benedict, Mark R.; Ayers, David C.; Calore, James D.; Richman, Robert A.

doi:10.1002/jbmr.5650091118

Cited by 14 publications

(1 citation statement)

References 53 publications

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“…In recent, clinical physicians have noted brain natriuretic peptide (BNP), which increases in patients with congestive heart failure [6], especially in those with severe hemodynamic impairment [4,21], and is a strong predictor of prognosis in patients with previous MI [11] and congestive heart failure [8].…”

Section: Introductionmentioning

confidence: 99%

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Choi¹,

Kim²,

Hyun³

et al. 2010

Journal of Life Science

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Cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB), and C-reactive protein (CRP) are routine cardiac markers for the diagnosis of cardiovascular disease. Recently, brain natriuretic peptide (BNP) has garnered attention as a marker of heart failure. This study was retrospectively designed to investigate the relationships between preoperative BNP, other cardiac markers levels and perioperative parameters in seventy-four adult patients that underwent off-pump coronary artery bypass grafting (OPCAB) and to assess its usefulness for predicting postoperative outcomes. Preoperative levels of BNP, cTnI, CK-MB, and CRP had significantly positive or negative correlations with echocadiographic parameters. There were significantly positive relationships between BNP, cTnI, CK-MB, and CRP concentration. Postoperative mechanical ventilation time had a positive correlation to preoperative levels of cTnI, CK-MB, and CRP, while ICU-staying period had a positive correlation with BNP, cTnI and CK-MB. These results reveal that a preoperative level of BNP is a good predictor and that its combination with cTnI, CK-MB, and CRP might be useful for diagnosis and comprehensive risk stratification of patients with coronary heart diseases, as well as prognosis of perioperative outcomes in OPCAB patients.

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Section: Introductionmentioning

confidence: 99%

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Choi¹,

Kim²,

Hyun³

et al. 2010

Journal of Life Science

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Physiologic Changes in Soft Tissue and Bone as a Function of Age

Fedarko¹,

Shapiro²

2001

Principles and Practice of Geriatric Surgery

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IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

Martel‐Pelletier¹,

Battista²,

Lajeunesse³

et al. 1998

Inflamm. res.

140

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In the context of joint biology, insulin-like growth factor-1 (IGF-1) is the most likely candidate to affect the anabolism of cartilage matrix molecules. Mechanisms for controlling the effects of IGF-1 include alterations in the level of this growth factor, its receptor and/or the IGF-1 affinity or availability to its receptor. Disturbance of any one of the above elements may induce a disregulation of the mechanisms involved in the local control of joint tissue integrity. This review focuses on recent studies of the IGF system, and the potential relevance of these results to in vivo effects in osteoarthritic (OA) tissues. It has been shown that, although the IGF-1's expression and synthesis are increased in OA cartilage, chondrocytes are hyporesponsive to IGF-1 stimulation. This phenomenon appears to be related, at least in part, to an increased level of IGF-binding proteins (IGFBP). The IGFBP have a high affinity for IGF-1, and appear to be important biomodulators for IGF action. Though to date seven IGFBP have been cloned and sequenced, disregulation in IGFBP-3 and -4 appears instrumental to arthritic disorders. Proteolytic activity directed against IGFBP has been found in both cartilage and bone; this activity appears to belong to serine- and/or metallo-proteases families. It has been suggested that a thickening of the subchondral bone participates in OA pathophysiology, and that IGF-1 production by bone and/or subchondral bone cells may contribute to these changes. An abnormal regulation of subchondral bone formation via an increase in the local activation of IGF-1 in bone cells, possibly via abnormal IGFBP synthesis due to aberrant PA/plasmin regulation of the IGF-I/IGFBP system, is believed to be a plausible hypothesis.

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Differential distribution of insulin-like growth factors and their binding proteins within bone: Relationship to bone mineral density

Cited by 14 publications

References 53 publications

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Physiologic Changes in Soft Tissue and Bone as a Function of Age

IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

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