1997
DOI: 10.1016/s0028-3908(97)00061-0
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Differential Distribution of [ 3 H]Sumatriptan Binding Sites (5-HT 1B , 5-HT 1D and 5-HT 1F Receptors) in Human Brain: Focus on Brainstem and Spinal Cord

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Cited by 121 publications
(58 citation statements)
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“…Autoradiographic studies of the 5-HT 1F receptor revealed high density of this receptor's binding sites in the frontal cortex, especially layer V, and substantia gelatinosa. Lower densities were found in the periaqueductal grey and globus pallidus (Castro et al 1997).…”
Section: -Ht 1e /5-ht 1fmentioning
confidence: 86%
See 1 more Smart Citation
“…Autoradiographic studies of the 5-HT 1F receptor revealed high density of this receptor's binding sites in the frontal cortex, especially layer V, and substantia gelatinosa. Lower densities were found in the periaqueductal grey and globus pallidus (Castro et al 1997).…”
Section: -Ht 1e /5-ht 1fmentioning
confidence: 86%
“…Color table indicates receptor binding potentials. For anatomical labeling of the same brain sections and brain surface image see Fig areas of the midbrain, especially periaqueductal gray (Castro et al 1997).…”
Section: -Ht 1b /5-ht 1dmentioning
confidence: 99%
“…In an attempt to characterize the receptors involved it has been suggested that the 5HT 1B receptors are present in very low concentrations in all these nuclei in man (below 12% of total specific binding), while the 5HT 1D receptors account for about 50% of the total specific sumatriptan binding [126]. In addition, a significant amount of 5HT 1F -binding sites can be seen [25,153]. The 5HT 1F site has been examined using a specific agonist LY334370 [170].…”
Section: ) What Is the Role Of The Trigeminocervical Complexs?mentioning
confidence: 99%
“…It is also unlikely that this effect was mediated via 5-HT "B receptors inducing an increase in ventricular afterload, since there was no effect on blood pressure or RPP at rest or any stage of exercise compared with placebo. A third possibility is that sumatriptan acts centrally by binding directly to 5-HT "D or 5-HT "F receptors, which have been shown to be present in autoradiographic studies of human brain tissue [26,27]. However, because sumatriptan is hydrophilic, it only crosses the intact blood-brain barrier in minute quantities (approximately 0n05 % of drug) that are thought to be clinically and pharmacologically insignificant [6,[9][10][11].…”
Section: Discussionmentioning
confidence: 99%