Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

“…The largest literature is for phytoestrogens. Effects of early exposure to genistein and resveratrol on the volumes of the AVPV [115,73] and SDN-POA [49,50,73,145,88,136] have been shown. Maternal resveratrol consumption resulted in larger AVPV and smaller SDN-POA volumes in adult male rats, with no effect on these endpoints in females [73].…”

“…Several recent studies have demonstrated direct effects of endocrine disruptors on hypothalamic neural circuitry, hypothalamic morphology, the phenotype of hypothalamic cells, and expression of steroid hormone receptors [141,115,134,113]. For illustrative purposes, the AVPV and SDN-POA will again be the focus of discussion, as the morphology of brain regions are particularly well studied in the endocrine disruption field.…”

Sexual Behavior: From Hormonal Regulation to Endocrine Disruption

“…In middle-aged males, chronic exposure to methoxychlor has also been shown to decrease time to ejaculation [52]. The published neuroanatomical data are presented in online supplementary Table 1: 6 studies described changes in the SDN or AVPV volume or cell number [47, 53-57], whereas 3 studies reported no effect [42, 58, 59]. In the studies reporting effects of exposure on the organization of sexually dimorphic populations, both similarities and differences were observed, depending on the type of neuronal cell analyzed.…”

“…In the studies reporting effects of exposure on the organization of sexually dimorphic populations, both similarities and differences were observed, depending on the type of neuronal cell analyzed. Indeed, increases in the number of tyrosine hydroxylase cells or AVPV volume have been described [47, 56, 57], suggesting demasculinization and/or feminization of this hypothalamic region. Opposite patterns have been observed, with either a decrease (resveratrol [47]; BPA [54]) or an increase in SDN volume or calbindin cell number (genistein or nonylphenol [55]; BPA or genistein [57]; BPA [53]).…”

Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals

“…Direct effects of EDCs have been shown on hypothalamic neurotransmitter systems, on the size of specific hypothalamic regions, as well as on numbers of cells expressing the estrogen receptor beta (13)(14)(15). These actions may underlie observations that prenatal exposure to low-doses of PCBs (16), or postnatal treatment with soy (17), significantly affected aspects of mating behavior in female rats.…”