Differential Display Analysis by Capillary Electrophoresis

Zhao, Xilin; George, Kimberly S

doi:10.1385/1-59259-116-7:259

Cited by 2 publications

(1 citation statement)

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“…Most of them were aimed at cationic ITP-MS and the analyzed substances were quaternary phosphonium ions [5], peptides and proteins [6][7][8][9][10], vitamins [10], and pesticides [4]. Anionic ITP-MS was reported only by Zhao et al [11][12][13] who used a reversed (EOF driven) arrangement in the positive-ion ESI mode for the analysis of monophosphate nucleosides, dinucleotides, and similar compounds. The reached sensitivities of the individual published applications cannot be directly compared as they strongly depend on the used instrumentation and applied procedure but the results with cationic ITP allow the conclusion that the LOD may typically reach the 10 −9 -10 −10 M range.…”

Section: Introductionmentioning

confidence: 99%

Electrolyte system strategies for anionic isotachophoresis with electrospray‐ionization mass‐spectrometric detection. 1. Regular isotachophoresis and free‐acid isotachophoresis

2013

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The subject of this work is the definition of a simple model based on general ITP theory that allows describing and predicting the behavior of ITP systems compatible with ESI-MS detection. The model is exemplified by anionic ITP of weak acids that represent an interesting potential application field of ITP-ESI-MS. Suitable ESI-compatible electrolyte systems of very simple composition are proposed including a special free-acid ITP arrangement. The properties of these systems are discussed using illustrative diagrams of their stacking windows. The use of anionic ITP-ESI-MS in negative-ion ESI mode is reported for the first time and its suitability for sensitive trace analysis is demonstrated. The presented ITP-ESI-MS application example comprises a free-acid ITP system formed of formic and propionic acids and direct injection analysis of ibuprofen and diclofenac in waters with quantitation limits of the order 10(-10) M.

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Section: Introductionmentioning

confidence: 99%