Differential Diagnosis of Virilism

Adrenocortical Hyperactivity in a Patient with Bronchial Carcinoma and Diabetes Mellitus

“…This rate of production was unaffected by the administration of 200 mg. of cortisone a day, the administered cortisone accounting for a rise of about 60 mg. in daily 17-ketogenic steroid excretion (Jepson et al, 1956) and the 17-ketosteroid excretion remaining essentially unchanged. Similar failure to suppress adrenocortical steroid production by means of cortisone has been reported in severe Cushing's syndrome due to adrenocortical hyperplasia resulting from increased production of corticotrophin (Segaloff et al, 1955;Laidlaw et al, 1955).…”

Adrenal Virilism Treated with Steroids

“…Segaloff et al (1955) observed that hydrocortisone acetate, when injected intramuscularly, is usually regarded as being relatively inactive on account of its very slow absorption, but this property is turned to advantage in the treatment of adrenal virilism, in which a sustained inhibition of corticotrophin is required.…”

“…Bishop et al (1952), Hubble (1952, and Bastenie et al (1953) have described cases treated for a short time with cortisone. Segaloff et al (1955), taking advantage of the very slow absorption of hydrocortisone acetate when injected intramuscularly, described the beneficial effects of this preparation in adrenal virilism when injected as infrequently as once a week or even once a fortnight.…”

Schwangerschaft und Geburt bei einer Patientin mit adrenogenitalem Syndrom

“…S p ä te r w u rd e dieser sog. « C o rtiso n te st» a u f die A n regung von Segaloff et al [15,16] auch von an d eren in die T h e ra pie e in g e fü h rt, und se ith e r ist vielerseits ü b er die m it ihm erzielten g ü n stig en E rgebnisse b e ric h te t w orden.…”