Differential Diagnosis of Tumors and Tumor-Like Lesions of Liver in Infancy and Childhood

Edmondson, Hugh A.

doi:10.1001/archpedi.1956.02060020170015

Cited by 240 publications

(161 citation statements)

References 36 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…The distinction between the two tumours may not be entirely academic, since it is likely that the factors which produce a truly embryonic tumour differ from those which give rise to a carcinoma of adult type. Some workers have attempted to make more elaborate classifications (Ishak and Glunz, 1967;Kasai and Watanabe, 1970) but our experience, in keeping with the findings of Edmondson (1956) Willis (1962) and Sinniah, Campbell and Colebatch (1974), is that there is a "grey zone" between the occasional poorly differentiated hepatocellular carcinoma and the purely epithelial hepatoblastoma. It is unsatisfactory to have no more objective criterion than the degree to which tumour cells resemble hepatic parenchyma, but we find that for practical diagnostic purposes there is often no other.…”

Section: Histologysupporting

confidence: 66%

“…In neighbouring Uganda, the proportion of liver cancers found at age 20 or less (4.2% Anthony, personal communication) is similar to the 4-7 % found in Kenya, and this confirms that the "strange absence" of juvenile cases (Edmondson, 1956) is an illusion as far as these highfrequency areas are concerned. Pathogenesis of hepatocellular carcinoma It seems that cirrhosis is seldom associated with hepatocellular carcinoma in very young children in the first decade of life, although individual examples have been reported (Jones, 1960).…”

Section: Geographical Variationsupporting

confidence: 61%

“…Edmondson (1956) found every grade of transition between the two, and Willis (1962) acknowledged that some tumours in older children are difficult to classify. The distinction between the two tumours may not be entirely academic, since it is likely that the factors which produce a truly embryonic tumour differ from those which give rise to a carcinoma of adult type.…”

Section: Histologymentioning

confidence: 99%

“…IT has been said that there is a "strange absence" of primary cancer of the liver in children in parts of the world in which it is common in adults (Edmondson, 1956;Fraumeni, Miller and Hill, 1968). Since these areas, which include Africa south of the Sahara, are mostly in countries with recently developed and inadequate medical resources, one should be cautious about accepting comparisons with more generously endowed communities.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Primary cancer of the liver in Kenyan children

Cameron¹,

Warwick²

1977

Br J Cancer

View full text Add to dashboard Cite

In 9 years in Kenya, 34 examples of primary liver cancer wer diagnosed in patients in the first two decades of life. This represents 4.7% of all liver cancers during this period. The larger proportion (29) were hepatocellular carcinoma. In the second decade, there was a notable association with macronodular cirrhosis. Analogy with experimental work suggests that cells in mitotic cycle may be more vulnerable to the effect of environmental carcinogens. Five examples of hepatoblastoma were identified at ages from 2 months to 14 years; none showed the features of "mixed" tumours. The ratio of hepatoblastoma to hepatocellular carcinoma was the reverse of that found in other large series of juvenile hepatic tumours. The histopathological features of these tumours are described and problems of their classification are discussed. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7

show abstract

Section: Histologysupporting

confidence: 66%

Section: Geographical Variationsupporting

confidence: 61%

Section: Histologymentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Primary cancer of the liver in Kenyan children

Cameron¹,

Warwick²

1977

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…The time of survival postrecurrence in these unusual cases has been 6.67 and 4.33 years. tures 1 and distinctive clinical behavior. 1,7 In our study (see Fig.…”

Section: Five-year Survivorsmentioning

confidence: 99%

Treatment of fibrolamellar hepatoma with subtotal hepatectomy or transplantation

Pinna¹

1997

Hepatology

View full text Add to dashboard Cite

Fibrolamellar hepatoma (FL-HCC) is an uncommon variant previously reported [4][5][6] ), less than 100 such cases can be found in the literature. 2,3,[7][8][9][10][11][12][13][14][15][16][17] In our series, we have compared the of hepatocellular carcinoma (HCC), distinguished by histopathological features suggesting greater differentiation than survival of patients with FL-HCC with that of patients with conventional HCC who were treated by the same team over conventional HCC. However, the optimal treatment and the prognosis of FL-HCC have been controversial. Follow-up a 27-year period. studies are available from 1 year to 27 years, after 41 patients with FL-HCC were treated with partial hepatectomy (PHx) PATIENTS AND METHODS (28 patients) or liver transplantation (13 patients). In thisCase Material retrospective study, the effect on outcome was determined for the pTNM stage and other prognostic factors routinely Between 1968 and 1995, 477 (range, 9-66; median, 25) (Fig. 1). The median follow-up was 58 tumor-free survival than those with negative nodes (P õ .015).{ 9.3 months. Patient survival was most adversely affected by the presence of vascular invasion (P õ .05). FL-HCC is an indolently grow- Clinicopathological Characteristicsing tumor of the liver, which usually was diagnosed in our patients at a stage too advanced for effective surgical treatmentThe pathology reports and operative findings were used to deterof most conventional HCC. Nevertheless, long-term survival mine: the principal tumor size, number of lesions, lobar distribufrequently was achieved with aggressive surgical treatment. tion, vascular and lymphatic tumor extension, surgical margins, When a subtotal hepatectomy could not be performed, total distant metastases, and the presence or absence of associated cirrhosis. When available, the tumor markers were recorded as well as hepatectomy (THx) with liver transplantation was a valuable the virus markers (hepatitis C virus, hepatitis B virus).

show abstract

Solitary Benign Adenoma of the Liver Associated with Progressive Hepatic Insufficiency

Jäger¹,

Nugent²

1958

AMA Arch Intern Med

View full text Add to dashboard Cite

Differential Diagnosis of Tumors and Tumor-Like Lesions of Liver in Infancy and Childhood

Cited by 240 publications

References 36 publications

Primary cancer of the liver in Kenyan children

Primary cancer of the liver in Kenyan children

Treatment of fibrolamellar hepatoma with subtotal hepatectomy or transplantation

Solitary Benign Adenoma of the Liver Associated with Progressive Hepatic Insufficiency

Contact Info

Product

Resources

About