Differential diagnosis of T2 hyperintense spinal cord lesions: Part B

Bou-Haidar, Pascal; Peduto, AJ; Karunaratne, Nishantha

doi:10.1111/j.1754-9485.2009.02067.x

Cited by 27 publications

(9 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MRI imaging is definitely sensitive for the diagnosis of a SCIWORA injury. 36 However, owing to the nature of the SCIWORA injury, it could be damaging the blood supply of the nerve. One hundred and twenty (28%) of the initial MRIs were normal; this is probably because the blood supply had been slowly 37 showed that adults most commonly presented with AIS grade C (39.7%) and grade D ( 22.8%).…”

Section: Discussionmentioning

confidence: 99%

Spinal cord injuries without radiologic abnormality in children: a systematic review

et al. 2015

View full text Add to dashboard Cite

Study design: Systematic review. Objectives: The objective of this study is to systematically review the literature for pediatric cases of spinal cord injuries without radiologic abnormality (SCIWORA) to investigate any possible relationship between initial neurologic impairment and eventual neurologic status. Setting: A university department of orthopedics. Methods: Following the preferred reporting items for systemic reviews and meta-analysis (PRISMA) guidelines for systematic review, the databases of PubMed and OvidSP were electronically searched for articles that use individuals under 18 years old, have trauma resulting in spinal cord injury and have no fractures or dislocations on radiographs. When available, the patients' age, sex, mechanism of injury and spinal cord level were recorded. Individuals with cervical injury, who had specific information on cervical level and mechanism of injury, were recorded as well. Patients who reported specific magnetic resonance imaging findings and the time from the injury were also reported. When possible, the American Spinal Injury Association Impairment Scale (AIS) was determined initially after the injury and then at last follow-up. Results: A total of 433 pediatric patients were identified with SCIWORA. The most prevalent mechanism of injury was sports-related injury cases (39.83%) followed by fall (24.18%) and motor vehicle-related (23.18%) injuries. The mean improvement recorded for all patients was 0.89 AIS grades. Conclusion:The most common mechanism of injury was sports-related and cervical injury, which occurred more frequently than other levels. Initial AIS grade A showed poorer outcomes in the pediatric population compared with the adult population. Initial presentation of D showed the highest likelihood of no permanent neurologic impairment (AIS of E).

show abstract

Section: Discussionmentioning

confidence: 99%

Spinal cord injuries without radiologic abnormality in children: a systematic review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Very few disease entities will have this classic MR appearance in isolation; acquired immune deficiency syndrome-associated vacuolar myelopathy and copper deficiency are some of the few entities known to be radiologically identical to SCD. (11,12) Demyelination, infection, autoimmune processes, neoplasm and vascular entities can also mimic SCD on MR imaging, yet these processes can potentially be differentiated on close inspection. (11) A recent review of T2 hyperintense spinal cord lesions by Bou-Haidar et al provides a concise outline for their differentiation.…”

Section: Discussionmentioning

confidence: 99%

Clinics in diagnostic imaging (190)

Pearce

Choy

Chen

2018

SMedJ

View full text Add to dashboard Cite

A 54-year-old Chinese man presented with a three-month history of progressive gait instability, leg weakness, bilateral ascending lower limb paraesthesias and numbness. The patient had no significant past medical history. Neurologic exam revealed 4/5 strength for knee extension and flexion bilaterally. Dorsiflexion and plantar flexion were rated at 4−/5 bilaterally. In addition, proprioception and vibration were markedly diminished in the lower limbs. Babinski reflex was downgoing bilaterally. Laboratory testing revealed macrocytic mean corpuscular volume (103 fL), low serum B12 levels (98 pmol/L), and increased serum homocysteine (25 µmol/L) and methylmalonic acid (310 nmol/L) levels. Bloodwork was negative for anti-intrinsic factor antibodies. What does the magnetic resonance (MR) image (Fig. 1) show? CMEArticle

show abstract

“…[4,5] The differential diagnosis for progressive spastic paraplegia includes degenerative, demyelinating, infectious, inflammatory, neoplastic, nutritional and vascular disorders. [9,10] Normal abdominal USG, cranial and spinal MRI's and history of chronic alcoholism provided the diagnosis of SCD due to chronic alcohol intake.…”

Section: Discussionmentioning

confidence: 99%

Progressive subacute combined degeneration: a severe relapse with discontinuation of vitamin B12 treatment

Özkan¹

2016

Turk J Phys Med Rehab

View full text Add to dashboard Cite

Subacute combined degeneration (SCD) is a rare neurological complication of vitamin B12 deficiency, characterized by the demyelination of dorsal and lateral spinal cord. Clinical manifestations of SCD are symmetric dysesthesia, disturbance of position sense and spastic paraparesis or tetraparesis. Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. The most consistent magnetic resonance imaging (MRI) finding is a symmetrical abnormally increased T 2 signal intensity confined to posterior or posterior and lateral columns in the spinal cord. We report a case with progressive SCD due to vitamin B12 deficiency. We aimed to discuss the clinical and radiological features of SCD in the literature review and emphasize the importance of early diagnosis and treatment.

show abstract

Differential diagnosis of T2 hyperintense spinal cord lesions: Part B

Cited by 27 publications

References 46 publications

Spinal cord injuries without radiologic abnormality in children: a systematic review

Spinal cord injuries without radiologic abnormality in children: a systematic review

Clinics in diagnostic imaging (190)

Progressive subacute combined degeneration: a severe relapse with discontinuation of vitamin B12 treatment

Contact Info

Product

Resources

About