Differential diagnosis of solid breast lesions: contribution of Doppler studies to mammography and gray scale imaging.

Özdemir, Ayşegül; Özdemi̇r, Hakan; Maral, İşıl; Konuş, Öznur; Ekşioğlu, Ayşe Seçil; Işık, Sedat

doi:10.7863/jum.2001.20.10.1091

Cited by 57 publications

(40 citation statements)

References 30 publications

(72 reference statements)

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“…Recent studies have reported that the addition of SWE to B-mode US improves its diagnostic performance in differentiating benign breast lesions from malignant breast lesions [15,16]. Additional use of Doppler US increased the specificity of B-mode US combined with mammography to 97.6% from 76.2% for diagnosing breast malignancies [17]. …”

Section: Introductionmentioning

confidence: 99%

Combination of shear-wave elastography and color Doppler: Feasible method to avoid unnecessary breast excision of fibroepithelial lesions diagnosed by core needle biopsy

et al. 2017

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BackgroundWe evaluated shear-wave elastography (SWE) and color Doppler ultrasonography (US) features for fibroepithelial lesions (FELs), and to evaluate their utility to differentiate fibroadenomas (FAs) and phyllodes tumors (PTs).MethodsThis retrospective study included 67 FELs pathologically confirmed (49 FAs, 18 PTs). B-mode US, SWE and color Doppler US were performed for each lesion. Mean elasticity (Emean), maximum elasticity (Emax), and vascularity were determined by SWE and Doppler US. Diagnostic performances were calculated to differentiate FAs and PTs. Equivocal FELs diagnosed by core needle biopsy (CNB) were further analyzed.ResultsMedian Emean and Emax were significantly lower for FAs than PTs (Emean, 15.7 vs. 66.7 kPa; Emax, 21.0 vs. 76.7 kPa, P<0.01). Low vascularity (0–1 vessel flow) on color Doppler US were more frequent in FAs than in PTs (P<0.01). SWE showed significantly higher specificities (Emean >43.9 kPa, 89.8%; Emax >46.1 kPa, 79.6%) than B-mode US (42.9%) (P<0.01) for differentiating PTs from FAs. Other diagnostic values of SWE and overall diagnostic values of Doppler US were not significantly different from B-mode US (P>0.05). The combination of SWE and Doppler US with ‘Emean>43.9 kPa or high vascularity (≥2 vessel flows)’ showed a higher area under the curve (0.786 vs. 0.687) and higher diagnostic values than B-mode US (sensitivity, 100 vs. 94.4%; specificity, 57.1 vs. 42.9%; positive predictive value, 46.2 vs. 37.8%; negative predictive value, 100 vs. 95.5%), without statistical significance (P>0.05). Of the 30 equivocal FELs, all lesions with ‘Emean≤43.9 kPa and low vascularity (0–1 vessel flow)’ (23.3%, 7/30) were finally confirmed as FAs by excision.ConclusionFAs have a tendency to have less stiffness and lower vascularity than PTs. Combined SWE and color Doppler US may help patients with equivocal FELs diagnosed by CNB avoid unnecessary excision.

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Section: Introductionmentioning

confidence: 99%

Combination of shear-wave elastography and color Doppler: Feasible method to avoid unnecessary breast excision of fibroepithelial lesions diagnosed by core needle biopsy

et al. 2017

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“…Besides interpretive criteria of B-mode sonography, color Doppler sonography and sonoelastography, as well as contrast enhanced harmonic ultrasound have been introduced to further characterize masses of the breast [11]. Color Doppler sonography has been shown a sensitivity of 68.0%-91.2% and a specificity of 92.7%-95.0% in differentiating malignant breast masses from benign lesions by visualizing the presence and morphology of blood vessels [4,14,16,19]. And also sonoelastography, which is an imaging modality that measures tissue stiffness, shows better specificity in distinguishing benign from malignant solid breast lesions than B-mode sonography alone and has become a routine tool during the last years [20].…”

Section: Introductionmentioning

confidence: 99%

High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma

Rjosk-Dendorfer

Reu

Deák

et al. 2014

Clinical Hemorheology and Microcirculation

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PURPOSE: To evaluate the use of color Doppler sonography and free hand sonoelastography in the assessment of breast fibroadenomas according to their size and shape. MATERIALS AND METHODS: From December 2012 to March 2013 women with 16 solid breast masses, classified as BI-RADS category 3 or 4 were examined with B-mode ultrasound, sonoelastography and color Doppler sonography. Lesions were subdivided according to their shape in round, ovoid or macrolobulated and according to their size (<2.0 cm or ≥2.0 cm). Two readers assessed sonoelastographic findings at 12.5 MHz using the tsukuba elasticity score and results of Doppler sonography using a score of 0, 1 or 2, depending on the degree of perfusion. RESULTS: Among the 16 examined lesions 3 showed a round shape, 9 were ovoid and in 4 cases a macrolobulated appearance could be seen. No significant differences concerning Tsukuba-score depending on various shapes of fibroadenomas in Bmode sonography could be shown (p = 0.91) and also comparison of Tsukuba-scores and size of masses revealed no significant differences (p = 1.0). Sizes of fibroadenomas ≥2 cm were significantly associated with an increased vascularization of the lesions (p = 0.04) and a macrolobulated appearance in B-mode sonography (p = 0.04). CONCLUSION: The combination of color Doppler sonography and sonoelastography in addition to B-mode sonography leads to an increased accuracy in distinguishing benign from malignant breast masses and to an improvement in characterization of fibroadenomas independent of their shape or size.

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“…Alongside cytological and histological examinations, imaging techniques have always played a key role in diagnosing breast cancer and in the characterisation of nodular diseases of the breast that may pose a differential diagnosis. Among the breast imaging techniques commonly used, the role, advantages and limitations of mammography [2][3][4], ultrasound (US) and colour Doppler ultrasound [4][5][6][7][8][9] are well known and extensively described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI

Caproni

Marchisio²,

Pecchi

et al. 2009

Eur Radiol

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Differential diagnosis of solid breast lesions: contribution of Doppler studies to mammography and gray scale imaging.

Abstract: Our data show that Doppler sonography is a beneficial adjunct to mammography and gray scale sonography for solid breast lesions 10 mm and smaller and those larger than 10 mm.

Cited by 57 publications

References 30 publications

Combination of shear-wave elastography and color Doppler: Feasible method to avoid unnecessary breast excision of fibroepithelial lesions diagnosed by core needle biopsy

Combination of shear-wave elastography and color Doppler: Feasible method to avoid unnecessary breast excision of fibroepithelial lesions diagnosed by core needle biopsy

High resolution compression elastography and color doppler sonography in characterization of breast fibroadenoma

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI

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