Differential diagnosis of gallbladder polypoid lesions using contrast-enhanced ultrasound

Miwa, Hideaki; Numata, Kazushi; Sugimori, Kazuya; Sanga, Katsuyuki; Hirotani, Akane; Tezuka, Shun; Goda, Yoshihiro; Irie, Kazuhiro; Ishii, Tomohiro; Kaneko, Takashi; Tanaka, Katsuaki; Maeda, Shin

doi:10.1007/s00261-018-1833-4

Cited by 23 publications

(26 citation statements)

References 26 publications

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“…However, about 60% benign lesions of GB were reported to be greater than 10 mm in some studies and caused unnecessary cholecystectomy. Meanwhile, some malignant lesions less than 10 mm increased the difficulty of diagnosis of US [7,24,25]. To our knowledge, the use of contrast agents can improve the diagnosis precision because of visualization of the feeding vessels to lesions and perfusion of blood, which overcomes the weakness of conventional ultrasound techniques that cannot depict tiny blood vessels and low-velocity flows [5].…”

Section: Discussionmentioning

confidence: 99%

“…According to previous reports, malignant lesions usually grow complicated tralesional vascularity [25,34]. Taking advantage of microvascular depiction on CEUS, we summarized the diagnostic values of individual studies based on vessel shape.…”

Section: Discussionmentioning

confidence: 99%

“…Further identification excluded 94 articles that were not of interest for this meta-analysis and 44 papers that failed to provide sufficient or related data for the calculation of diagnostic accuracy. Finally, 21 articles satisfying the inclusion criteria were included and analyzed [2,7,8,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. The demonstration of study search flow can be seen in Fig.…”

Section: Study Identificationmentioning

confidence: 99%

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RETRACTED ARTICLE: Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy

Xiaoming

Jing

2020

BMC Med Inform Decis Mak

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Background The diagnosis between benign and malignant gallbladder lesions is sometimes difficult. The objective of this study is to assess whether contrast-enhanced ultrasound (CEUS) and contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) can be an accurate method for detecting gallbladder malignancy and to determine which imaging signs can be indicative of malignancy. Methods A study search of PubMed, Elsevier, and Sciencedirect was performed in May 2019. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were used to examine the accuracy of CEUS and CH-EUS. Results Twenty-one studies were included in the meta-analysis. The pooled sensitivities of CEUS and CH-EUS were 0.81 (0.75–0.86) and 0.92 (0.86–0.95); the specificities were 0.94 (0.90–0.96) and 0.89 (0.69–0. 97); the DORs were 64 (32–127) and 89 (22–354); and the area under the SROC curves were 0.90 (0.87–0.92) and 0.92 (0.90–0.94). On CEUS, the diagnostic criterion for gallbladder malignancy according to four features were analyzed. Sensitivity and specificity were 0.75 (0.65–0.83) and 0.98 (0.85–1.00) for integrity of gallbladder wall; 0.69 (0.55–0.81) and 0.89 (0.77–0.95) for heterogeneous enhancement; 0.81 (0.71–0.88) and 0.88 (0.76–0.94) for irregular vessels; and 0.81 (0.66–0.91) and 0.75 (0.59–0.86) for washout time within 28 s. On CH-EUS, heterogeneous enhancement could be indicative of malignant lesions with a sensitivity of 0.94 (0.85–0.97); and the specificity was 0.92 (0.71–0.98). Conclusions CEUS and CH-EUS are promising and reliable imaging modalities with a high sensitivity and specificity for the diagnosis of gallbladder malignancy. CH-EUS might be more sensitive than CEUS with a higher sensitivity. In addition, irregular tralesional vessels and washout time within 28 s on CEUS and heterogeneous enhancement on CH-EUS are indicative of malignancy. However, larger scale and well-designed studies are warranted to verify our results.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Identificationmentioning

confidence: 99%

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RETRACTED ARTICLE: Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy

Xiaoming

Jing

2020

BMC Med Inform Decis Mak

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“…Three-dimensional contrastenhanced patterns are useful for the differential diagnosis of solid pancreatic lesions, with a reported diagnostic accuracy of 90.5% [188]. For the gallbladder, Sonazoid CEUS showed 94% sensitivity, 89% specificity, and 92% accuracy in the differential diagnosis of malignant and benign polypoid lesions [189], and 85.2% accuracy in the diagnosis of gangrenous cholecystitis [190]. [191,192].…”

Section: Contrast-enhanced Ultrasound For Pancreatobiliary Diseasementioning

confidence: 99%

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

et al. 2020

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The first edition of the guidelines for the use of ultrasound contrast agents was published in 2004, dealing with liver applications. The second edition of the guidelines in 2008 reflected changes in the available contrast agents and updated the guidelines for the liver, as well as implementing some nonliver applications. The third edition of the contrast-enhanced ultrasound (CEUS) guidelines was the joint World Federation for Ultrasound in Medicine and Biology-European Federation of Societies for Ultrasound in Medicine and Biology (WFUMB-EFSUMB) venture in conjunction with other regional US societies such as Asian Federation of Societies for Ultrasound in Medicine and Biology, resulting in a simultaneous duplicate on liver CEUS in the official journals of both WFUMB and EFSUMB in 2013. However, no guidelines were described mainly for Sonazoid due to limited clinical experience only in Japan and Korea. The new proposed consensus statements and recommendations provide general advice on the use of Sonazoid and are intended to create standard protocols for the use and administration of Sonazoid in hepatic and pancreatobiliary applications in Asian patients and to improve patient management.

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“…Sometimes differentiating gallbladder cancer from GP is not easy preoperatively, but utilizing contrast enhanced ultrasound can make this goal approachable with acceptable sensitivity and specifi city [40]. It was considered that size of GP of 1 cm is not strongly diagnostically accurate, and there is a need for surgical removal of gallbladder [41,42].…”

Section: Methodsmentioning

confidence: 99%

Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study

Alharbi¹

2019

J Surg Surgical Res

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Introduction: Gallbladder polyps (GP), especially adenomatous, is quite rare. The prevalence of GP globally is variable, its importance comes from its potential to progress to gallbladder adenocarcinoma. Methods: Cross sectional study of patients who had laparoscopic cholecystectomy, March 2009-sept 2017 in a community hospital in sulayel area in Saudi Arabia, to evaluate the prevalence of adenomatous gallbladder polyps in the pathology specimens. Results: A total of 1205 patient have been examined ,the prevalence of adenomatous gallbladder polyps is approaching (0.4%) ,no foci of malignancy were found.it is still below the international prevalence rate. 107 (8.9 %) patients with acute cholecystitis, 119 (9.9 %)acute on chronic cholecystitis, 11 (0.9 %) with complicated cholecystitis and 968 (80.3 %) patients with chronic cholecystitis. Discussions: The prevalence of adenomatous gallbladder polyps is approaching 0.4%, no foci of malignancy were found. It is still below the international prevalence rate. Conclusion: Low prevalence rate of adenomatous gallbladder polyps compared to international levels may need further studies to explore the reasons behind.

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Differential diagnosis of gallbladder polypoid lesions using contrast-enhanced ultrasound

Cited by 23 publications

References 26 publications

RETRACTED ARTICLE: Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy

RETRACTED ARTICLE: Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

Gallbladder Adenoumatous Polyps prevelance in Cholcystectomy in Saudi Arabia-cross sectional study

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