Differential diagnosis of gallbladder neoplastic polyps and cholesterol polyps with radiomics of dual modal ultrasound: a pilot study

Abstract

Purpose To verify whether radiomics techniques based on dual-modality ultrasound consisting of B-mode and superb microvascular imaging (SMI) can improve the accuracy of the differentiation between gallbladder neoplastic polyps and cholesterol polyps. Methods A total of 100 patients with 100 pathologically proven gallbladder polypoid lesions were enrolled in this retrospective study. Radiomics features on B-mode ultrasound and SMI of each lesion were extracted. Support vector machine was used to classify adenomas and cholesterol polyps of gallbladder for B-mode, SMI and dual-modality ultrasound, respectively, and the classification results were compared among the three groups. Results Six, eight and nine features were extracted for each lesion at B-mode ultrasound, SMI and dual-modality ultrasound, respectively. In dual-modality ultrasound model, the area under the receiver operating characteristic curve (AUC), classification accuracy, sensitivity, specificity, and Youden’s index were 0.850 ± 0.090, 0.828 ± 0.097, 0.892 ± 0.144, 0.803 ± 0.149 and 0.695 ± 0.157, respectively. The AUC and Youden’s index of the dual-modality model were higher than those of the B-mode model (p < 0.05). The AUC, accuracy, specificity and Youden’s index of the dual-modality model were higher than those of the SMI model (p < 0.05). Conclusions Radiomics analysis of the dual-modality ultrasound composed of B-mode and SMI can improve the accuracy of classification between gallbladder neoplastic polyps and cholesterol polyps.

New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases

“…Artificial intelligence, in particular radiomic analysis based on B-mode and SMI, has been applied in the sonographic differentiation between neoplastic and cholesterol polyps [119].…”

Advances in the management of gallbladder polyps: establishment of predictive models and the rise of gallbladder-preserving polypectomy procedures

“…The improved ensemble model achieved a specificity of 88.35%, AUC of 0.9082, and accuracy of 87.61%, implying a great performance in classifying GBPs of < 20 mm, especially for those > 10 mm. The models built by Yuan et al achieved good results in identifying the nature of GBPs [ 19 , 20 ]. Han integrated Radscore, which is calculated by taking 6 radiomics factors into the radiomics model, into the nomogram [ 21 ].…”

Current Status and New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases

“…[139] Artificial intelligence, in particular radiomic analysis based on B-mode and SMI, has been applied in the sonographic differentiation between neoplastic and cholesterol polyps. [140] In recent years, some authors have developed scoring systems to predict the histologic type of gallbladder polyps, based on pre-operative sonographic findings and/or patients characteristics. [141,142] Polyps > 10 mm in size have been considered as preinvasive adenomas or papillary neoplasms, while polyps from 6 to 10 mm in size rarely progress to malignancy.…”