Differential Diagnosis of Cushing’s Syndrome

Javorsky, Bradley R.; Carroll, Ty B.; Findling, James W.

doi:10.1007/978-1-4614-0011-0_7

Cited by 8 publications

(5 citation statements)

References 95 publications

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“…DHEA was chosen as a biomarker for this meta-analysis, with a reason to assess the significance of stress in this syndrome. DHEA is an important stress marker released commonly from the adrenal cortex in response to ACTH when provoked by a stressor [ 51 ]. Physiologically, circulating DHEA is also produced and released in small amounts from the ovaries and testis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

et al. 2021

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Background Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal. Objective To perform meta-analysis and find the association between stress and the syndrome. Data sources Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms. Study selection Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles. Data extraction Two authors independently extracted the articles and qualified the final studies. Data synthesi Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59–1.71).Heterogeneity was statistically significant as well (I2 = 95%). Conclusion Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.

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Section: Discussionmentioning

confidence: 99%

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

et al. 2021

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“…3,5,6 GH exerts its catabolic effects through a postreceptor defect in the action of insulin on target cells, leading to decreased carbohydrate utilization, reduced insulin sensitivity and hyperglycemia. 5,7 GH also stimulates the production of IGF-1, primarily by the liver, resulting in increased protein synthesis and excessive tissue growth. 8 The diagnosis of feline acromegaly currently relies on demonstrating the combination of insulin-resistant diabetes mellitus (DM), typical physical changes and increased serum IGF-1 concentrations.…”

Section: Introductionmentioning

confidence: 99%

Abdominal ultrasonographic findings in acromegalic cats

Lourenço

Randall

Seiler

et al. 2014

Journal of Feline Medicine and Surgery

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“…Соматостатин-рецепторная сцинтиграфия -один из перспективных методов исследования, особенно при получении противоречивых данных КТ и МРТ, так как рецепторы к соматостатину были обнаружены на поверхности большинства клеток, происходящих из нейроэндокринной ткани [14]. Выбранная нами в качестве подтверждающего топического метода, сцинтиграфия с технецием-тектротидом показала отрицательный результат в отношении выявленного пульмонального очага.…”

Section: Discussionunclassified

Ectopic ACTH-syndrome caused by neuroendocrine tumor of lung

Dzeranova

Pigarova

Selivanova

et al. 2018

Khir. Z. im. N.I. Pirogova

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Эктопическая секреция адренокортикотропного гормона (АКТГ-эктопический синдром)-сравнительно редкое нейроэндокринное заболевание. В связи с развитием гиперкортизолемии оно характеризуется формированием тяжелых осложнений со стороны различных органов и систем, что диктует необходимость своевременного установления диагноза и проведения радикальной терапии. Представленный клинический случай (пациентка молодого возраста с АКТГ-продуцирующей опухолью легкого, диагностический поиск которой продолжался около года на фоне сохранения эндогенного гиперкортицизма, а лечение завершилось развитием ярко выраженной послеоперационной надпочечниковой недостаточностью) демонстрирует трудности в ведении больных с данной нозологией.

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Differential Diagnosis of Cushing’s Syndrome

Cited by 8 publications

References 95 publications

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

Abdominal ultrasonographic findings in acromegalic cats

Ectopic ACTH-syndrome caused by neuroendocrine tumor of lung

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