Differential Diagnosis of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder by Means of Inhibitory Control and ‘Theory of Mind’

Bühler, Eva; Bachmann, Christian; Goyert, Hannah; Heinzel‐Gutenbrunner, Monika; Kamp‐Becker, Inge

doi:10.1007/s10803-011-1205-1

Cited by 70 publications

(49 citation statements)

References 63 publications

(76 reference statements)

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“…Some have proposed that both ADHD and ASD are part of a category of 'empathy disorders' [130]. Other research [131][132][133], however, suggests that children with ADHD are not as impaired as children with ASD on theory of mind tasks.…”

Section: Neuropsychological/cognitivementioning

confidence: 99%

The comorbidity of ADHD and autism spectrum disorder

Antshel

Zhang-James

Faraone

2013

Expert Review of Neurotherapeutics

123

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ADHD and autism spectrum disorder are common psychiatric comorbidities to each another. In addition, there is behavioral, biological and neuropsychological overlap between the two disorders. There are also several important differences between autism spectrum disorder and ADHD. Treatment strategies for the comorbid condition will also be reviewed. Future areas of research and clinical need will be discussed.

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Section: Neuropsychological/cognitivementioning

confidence: 99%

The comorbidity of ADHD and autism spectrum disorder

Antshel

Zhang-James

Faraone

2013

Expert Review of Neurotherapeutics

123

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“…Some studies evidence that the comorbid group is the group with the most pronounced brain function abnormalities (Chantiluke et al, 2014) and more impaired on daily-life executive functioning (Dajani et al, 2016). Similarly, studies that had focused on response inhibition report that ADHD and ASD+ADHD patients show more dysfunction on inhibitory control compared to the ASD patients (Bühler et al, 2011;Sinzig et al, 2008b;Tye et al, 2014). In addition, even studies that do not find differences between the clinical groups on response inhibition suggest a tendency of decreased performance in the comorbid group (Neely et al, 2016;Pitzianti et al, 2016;Takeuchi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…No significant differences between clinical groups on inhibit performances were found in three studies (Neely, Green, Sciberras, Hazell, & Anderson, 2016;Pitzianti et al, 2016;Takeuchi et al, 2013). In three studies, ADHD and ASD+ADHD patients demonstrated more impairment in inhibitory control compared to the ASD patients (Bühler et al, 2011;Sinzig, Morsch, Bruning, Schmidt, & Lehmkuhl, 2008b;Tye et al, 2014). In one study, the ASD+ADHD group had more deficits on inhibition compared to other groups (Chantiluke et al, 2014 Pitzianti et al (2016) found the ADHD+HFA was impaired on response inhibition when compared with the TD group using a computerized task of Go/No-Go.…”

Section: Response Inhibitionmentioning

confidence: 98%

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A Review of Executive Functions in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder

Berenguer¹,

Miranda²,

Leader³

2018

JEDP

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Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are two of the most common childhood-onset neurodevelopmental disorders. Literature has shown different patterns of deficits in executive functioning in children with ASD and ADHD. To date few studies have examined executive functions in both ASD and ADHD and with mixed results.The current study provides the first systematic review to explore distinct executive function components (attention problems, response inhibition, working memory, planning and flexibility) that underlie the specific deficits seen in children and adolescents with both ASD and ADHD disorders. Findings provide evidence for executive dysfunctions across different key components such as attention, response inhibition and verbal working memory in children and adolescents with ASD and comorbid ADHD clinical symptoms. This research explores the neurocognitive profile of the comorbid condition, which is also critical for designing appropriate interventions.

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“…For instance, ADHD and ASD are highly comorbid and both disorders share similar neurocognitive deficits, including poor theory of mind. 28 Several studies have pointed out that there are altered blood vasopressin levels in ASD. 4,29 Furthermore, a recent study reported a positive correlation between plasma vasopressin levels and theory of mind ability in ASD subjects and posited that blood vasopressin levels are a robust biomarker of theory of mind ability in children with ASD.…”

Section: Discussionmentioning

confidence: 99%

Exploratory study to evaluate plasma vasopressin and apelin‐13 levels in children with attention‐deficit hyperactivity disorder

Bi̇lgi̇ç

Toker

Uysal

2016

Psychiatry Clin Neurosci

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Aim: Vasopressin exerts robust influences on social communication and behavior in humans. Apelin is a relatively novel neuropeptide that could counteract vasopressin's actions and has been shown to be closely related with a broad range of physiological functions. Abnormalities in vasopressin and apelin have been detected in a variety of psychiatric disorders, but their relation to attention-deficit hyperactivity disorder (ADHD) is unknown. In the present study, we explored the plasma levels of vasopressin and apelin-13 in children with ADHD.Methods: Thirty-four children with ADHD and 36 healthy controls were enrolled in this study. The severity of ADHD symptoms was assessed via Conners' Parent Rating Scale and Conners' Teacher Rating Scale. Plasma levels of vasopressin and apelin-13 were measured using commercial enzymelinked immunosorbent assay kits. Results:The mean plasma apelin-13 levels were significantly higher in male children with ADHD than in male control subjects; no significant difference was found between the groups for plasma apelin-13 levels in girls or in the entire subject cohort. Plasma vasopressin levels did not show any significant differences between groups. There were no significant correlations between plasma levels of these neuropeptides and scores for Conners' Parent Rating Scale and Conners' Teacher Rating Scale. Conclusion:Our results suggest a sex-specific association between plasma apelin-13 levels and ADHD. Apelin-13 may play a role in the etiopathogenesis of ADHD either with a direct impact on the apelin receptor or via its opposing effect on the vasopressinergic system. Key words: apelin-13, attention-deficit hyperactivity disorder, children, plasma, vasopressin.A TTENTION-DEFICIT HYPERACTIVITY DISOR-DER (ADHD) is a childhood-onset neurodevelopmental condition characterized by inattention, hyperactivity, and/or impulsivity that can persist into adulthood with deleterious effects on social, academic, and behavioral outcomes.1 The etiology of ADHD involves complex interactions of neuroanatomical and neurochemical systems, but the precise neurobiological mechanisms underlying the disorder are currently unclear. Understanding the etiopathogenesis of ADHD would aid in both its diagnosis and in the development of new treatments for this complex disorder.The vasopressinergic system in the brain participates in the modulation of social behaviors, including social communication, parental care, parent-offspring bonding, pair-bonding, and sexual behavior.2 Because social deficiencies are core symptoms of autism spectrum disorders (ASD), in recent years, a growing number of studies have investigated the potential relation between the vasopressinergic system and ASD. [3][4][5] These studies have yielded conflicting results regarding the alteration of blood vasopressin concentrations

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Differential Diagnosis of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder by Means of Inhibitory Control and ‘Theory of Mind’

Cited by 70 publications

References 63 publications

The comorbidity of ADHD and autism spectrum disorder

The comorbidity of ADHD and autism spectrum disorder

A Review of Executive Functions in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder

Exploratory study to evaluate plasma vasopressin and apelin‐13 levels in children with attention‐deficit hyperactivity disorder

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