“…There is a lack of operational guidance for cleaning and disinfection of VR HMDs to allow for safe transfer between clinicians. This paper documents the process of developing an operational guide for cleaning and disinfection of HMDs in New South Wales (NSW), Australia ( 1 ). We first describe the emergence of VR as a supporting modality for clinical education, the principles of infection prevention and control and describe how these principles underpinned the development of a guideline for VR cleaning and disinfection to ensure the safety of users.…”