The behavior of the nuclear matter response in the region of large momentum transfer, in which plane wave impulse approximation predicts the onset of y-scaling, is discussed. The theoretical analysis shows that scaling violations produced by final state interactions are driven by the momentum dependence of the nucleon-nucleon scattering cross section. Their study may provide valuable information on possible modifications of nucleon-nucleon scattering in the nuclear medium.PACS numbers: 13.60. Hb, 13.75.Cs, 25.30.Fj Inclusive scattering of high energy electrons off nuclear targets has long been recognized as a powerful tool to measure the nucleon momentum and removal energy distribution [1]. The underlying picture is that at large momentum transfer electron-nucleus scattering reduces to the incoherent sum of elementary scattering processes involving individual nucleons, distributed in momentum and removal energy according to the spectral function P (k, E). In the early seventies, West first pointed out [2] that, if the electron-nucleon processes are elastic and the final state state interactions between the struck particle and the spectator system can be neglected, the nuclear response S(q, ω), which generally depends upon both momentum (q) and energy (ω) transfer, exhibit scaling, i.e. it can be simply related to a function of only one kinematical variable, denoted y. Within the simplest nonrelativistic approximation, y can be identified with the minimum projection of the nucleon momentum along the direction of the momentum transfer, while the scaling function F (y) = (q/m)S(q, ω), where m denotes the nucleon mass, can be directly written in terms of the nucleon momentum distribution.The approach to y-scaling in few-nucleon systems [3,4] and medium-heavy nuclei [5] has been experimentally investigated at SLAC in the kinematical domain extending up to Q 2 = q 2 − ω 2 ∼ 3 (GeV/c) 2 . Recent measurements carried out at TJNAF using Carbon, Iron and Gold targets have extended the Q 2 range up to ∼ 7 (GeV/c) 2 [6]. The available data, plotted as a function of y, display a striking overall scaling behavior at y < 0, corresponding to ω < ω QE (ω QE = Q 2 /2m, is the energy transfer associated with elastic scattering off a free nucleon at rest), indicating that elastic scattering off individual nucleons is indeed the dominant reaction mechanism in that region. However, the analysis of the Q 2 -dependence at fixed y shows sizeable scaling violations at y < −0.2 GeV/c and Q 2 < 3 (GeV/c) 2 , to be ascribed mainly to final state interactions (FSI). Recenlty, Donnelly and Sick [7] have also shown that the y-scaling functions of different nuclei exhibit scaling of the second kind in the new variable ψ ′ = y/k F , k F being the Fermi momentum.The relevance of FSI in the kinematical regime of the SLAC data has been systematically studied in refs. [8][9][10], within a microscopic many-body approach in which nucleon-nucleon (NN) correlations are consistently taken into account in both the initial and final state. The results of...