Differential coupling of the P2Y1 receptor to Gα14 and Gαq/11 proteins during the development of the rat salivary gland

Baker, Olga J.; Camden, Jean M.; Ratchford, Ann M.; Seye, Cheikh I.; Erb, Laurie; Weisman, Gary A.

doi:10.1016/j.archoralbio.2005.10.004

Cited by 17 publications

(18 citation statements)

References 61 publications

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“…Most of these can combine to form heterooligomers, resulting in altered pharmacological properties. The eight subtypes of P2Y receptors (P2Y 1,2,4,6,11,12,13,14 ) are activated by ATP, ADP, UTP, UDP, or nucleotide sugars, depending on the subtype, and couple to differential intracellular signaling pathways [104]. In rodents, the most common experimental animals, the ligand preference (in brackets) is as follows: P2Y 1 (ADP, ATP), P2Y 2 (UTP, ATP), P2Y 4 (UTP, ATP), P2Y 6 (UDP), P2Y 11 (ATP), P2Y 12 (ADP), P2Y 13 (ADP), and P2Y 13 (UDP glucose and other nucleotide sugars).…”

Section: Signaling Via Extracellular Nucleotidesmentioning

confidence: 99%

Nucleotide signaling in nervous system development

Zimmermann

2006

Pflugers Arch - Eur J Physiol

156

124

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The development of the nervous system requires complex series of cellular programming and intercellular communication events that lead from the early neural induction to the formation of a highly structured central and peripheral nervous system. Neurogenesis continuously takes place also in select regions of the adult mammalian brain. During the past years, a multiplicity of cellular control mechanisms has been identified, ranging from differential transcriptional mediators to inducers or inhibitors of cell specification or neurite outgrowth. While the identification of transcription factors typical for the stage-specific progression has been a topic of key interest for many years, less is known concerning the potential multiplicity of relevant intercellular signaling pathways and the fine tuning of epigenetic gene regulation. Nucleotide receptors can induce a multiplicity of cellular signaling pathways and are involved in multiple molecular interactions, thus opening the possibility of cross talk between several signaling pathways, including growth factors, cytokines, and extracellular matrix components. An increasing number of studies provides evidence for a role of nucleotide signaling in nervous system development. This includes progenitor cell proliferation, cell migration, neuronal and glial cellular interaction and differentiation, and synaptic network formation.

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Section: Signaling Via Extracellular Nucleotidesmentioning

confidence: 99%

Nucleotide signaling in nervous system development

Zimmermann

2006

Pflugers Arch - Eur J Physiol

156

124

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“…Depending on the subtype of P2Y receptor, nucleotides such as ATP, ADP, UTP and UDP activate a variety of intracellular signaling cascades, most notably phospholipase C and an increase in [Ca 2+ ] i , activation or inhibition of adenylyl cyclase, coupling to ion channels, activation of the mitogen-activated (MAP) kinase pathways, and induction of immediate early genes Majumder et al, 2007). Importantly, the signaling pathways elicited and the functional outcome vary not only between P2Y receptors but also with the cell context (Fam et al, 2003;Fam et al, 2005;Baker et al, 2006;Kudirka et al, 2007).…”

Section: The Nucleotides Adpβs and Utp And Egf Elicit Converging But mentioning

confidence: 99%

Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells

Grimm

Messemer

Stanke

et al. 2009

Journal of Cell Science

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The adult subventricular zone (SVZ) contains astrocyte-like stem cells capable of generating new neurons for the olfactory bulb. Adult neurogenesis is driven by a variety of signal systems that can induce synergistic or opposing cellular responses. It is therefore important to gain insight into the underlying downstream signaling pathways. We have previously shown that the nucleotides ADPβS and UTP induce rapid Ca2+ transients in cultured SVZ-derived adult neural progenitors and augment growth-factor-mediated progenitor cell proliferation. Here, we investigated signaling pathways elicited by ADPβS, UTP and epidermal growth factor (EGF). All three agonists elicit ERK1/2 and CREB phosphorylation but the temporal characteristics differ between the nucleotides and EGF. Differentiation of the progenitors alters the receptor profile. Oligodendrocytes and young neurons, but not astrocytes, lose responsiveness to the agonists. Inhibition experiments are indicative of an ADPβS-elicited EGF receptor transactivation. Whereas UTP acts via the P2Y2 receptor, ADPβS exerts its function via the P2Y1 receptor and the P2Y13 receptor. Our data demonstrate that nucleotides and EGF induce converging, but also differential, intracellular signaling pathways and suggest that they carry the potential to act synergistically in the control of cell proliferation and cell survival in adult neurogenesis.

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“…In lacrimal glands, a P2Y 2 agonist was found to improve ocular surface health in a rat dry eye model based on the induction of increased tear fluid secretion and the release of glycoprotein-containing moieties from goblet cells (25). However, there are few data on P2Y receptors of parotid glands (3,45,56). Therefore, it is necessary to understand whether the effect of ATP on parotid glands is mediated by metabotropic P2Y receptors under physiological conditions.…”

Section: Intracellular Camentioning

confidence: 99%

“…These data indicated that ATP-induced responses are mediated by P2, but not P1 receptors. It has been reported that parotid glands express some ionotropic P2X purinoceptors (8,10,18,33,34); however, there are few studies of metabotropic P2Y receptors in the parotid gland (3,45,56). Therefore, we analyzed the potential contribution of P2 receptor subtypes to ATP-induced [Ca 2+ ] i increases in parotid gland acinar cells using receptor-specific agonists and antagonists.…”

Section: P2 Receptor Mrna Expression In Parotid Gland Acinar Cellsmentioning

confidence: 99%

“…The acinar cells secrete primary saliva, which is a plasma-like, isotonic fluid. The ductal cells reabsorb Na + and Cl − from primary saliva and excrete K + and HCO 3 − into the final saliva. The salivary secretion from acini and modification of the electrolytes in ducts are regulated by an increase in the intracellular Ca 2+ concentration ([Ca 2+ ] i ) through the activation of Ca 2+ -dependent ion channels and transporters (39).…”

Section: +mentioning

confidence: 99%

See 1 more Smart Citation

<b>P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid </b><b>glands </b>

et al. 2016

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Adenosine 5'-triphosphate (ATP) can act as an extracellular signal that regulates various cellular functions. The present study aimed to determine which purinoceptors play a role in ATP ] i increase, and UTP and α,β-MeATP had no effect. The potency order of ATP analogs (2-MeSATP > ATP >> UTP) suggested that P2Y 1 and P2Y 12 play a significant role in the cellular response to ATP. RT-PCR revealed that P2X 2,4,7 and P2Y 1,2,10,12,14 were expressed in acinar cells. Ca 2+ -dependent exocytotic secretion of amylase was detected in parotid glands. These findings indicated that ATP activates P2Y receptors more than

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Differential coupling of the P2Y1 receptor to Gα14 and Gαq/11 proteins during the development of the rat salivary gland

Cited by 17 publications

References 61 publications

Nucleotide signaling in nervous system development

Nucleotide signaling in nervous system development

Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells

<b>P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid </b><b>glands </b>

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