Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use

Ehinger, Yann; Phamluong, Khanhky; Darevesky, David; Welman, Mélanie; Moffat, Jeffrey J.; Sakhai, Samuel A.; Whiteley, Ellanor L.; Berger, Anthony L.; Laguesse, Sophie; Farokhnia, Mehdi; Leggio, Lorenzo; Lordkipanidzé, Marie; Ron, Dorit

doi:10.1111/adb.12890

Cited by 20 publications

(16 citation statements)

References 87 publications

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“…Hsa-miR-151a-3p was implicated in SSRI responsiveness and possibly in the clinical response to antidepressant drugs via down-regulating CHL1 expression (Oved et al, 2017). Hsa-miR-195-5p was increasingly expressed and targeted BDNF in rats with the rapid onset of heavy alcohol use (Ehinger et al, 2021). The altered expression of these DE-miRNAs was also found in individuals with other comorbid psychiatric disorders sharing genetic overlap with autism, including major depressive disorder, attention-deficit/hyperactivity disorder, and Alzheimer's disease (Mendes-Silva et al, 2016;Sánchez-Mora et al, 2019;Zadehbagheri et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population

Wang

et al. 2022

Front. Genet.

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Autism is a complex neurodevelopmental disorder. However, its etiology is still unknown. MicroRNAs (miRNAs) are key post-transcriptional regulators. They play an important role in neurodevelopment and brain functions and may be involved in the pathogenesis of autism. Previous studies indicated altered expression of miRNAs in patients with autism. However, the findings were not consistent, and further explorations were needed. This study aimed to investigate whether miRNAs were dysregulated in autism. We examined the expression of 30 brain-specific autism-associated miRNAs in 110 patients with autism and 113 controls in the Han Chinese population using quantitative reverse transcription–polymerase chain reaction. The results demonstrated that 10 miRNAs (hsa-miR-191-5p, hsa-miR-151a-3p, hsa-miR-139-5p, hsa-miR-181a-5p, hsa-miR-432-5p, hsa-miR-181b-5p, hsa-miR-195-5p, hsa-miR-328-3p, hsa-miR-106a-5p, and hsa-miR-484) were significantly differentially expressed (false discovery rate <0.05). All of them were up-regulated in patients with autism compared with controls. The targets of these miRNAs were enriched for genes and pathways related to neurodevelopment, brain functions and autism. These findings suggested the participation of these 10 miRNAs in the pathogenesis of autism in the Han Chinese population.

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Section: Discussionmentioning

confidence: 99%

Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population

Wang

et al. 2022

Front. Genet.

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“…Ehinger et al indicated an inverse correlation between blood serum BDNF levels and alcohol intake in rapid-onset and late-onset AUD rats. In contrast, the expression of miR-30a-5p, miR-195-5p, miR-191-5p and miR-206-3p, which were known to target BDNF, were robustly elevated in the serum of rapid-onset AUD rats [86]. It was found that the expression of miR-206 was significantly up-regulated in medial prefrontal cortex (mPFC) of rats with a history of AUD.…”

Section: The Mirnas Expression and Their-related Mechanisms In Aud An...mentioning

confidence: 98%

Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder

Wang¹,

Liu²,

Xia³

et al. 2023

Int. J. Biol. Sci.

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Alcohol use disorder (AUD) is one of the most prevalent neuropsychological disorders worldwide, and its pathogenesis is convoluted and poorly understood. There is considerable evidence demonstrating significant associations between multiple heritable factors and the onset and progression of AUD. In recent years, a substantial body of research conducted by emerging biotechnologies has increasingly highlighted the crucial roles of noncoding RNAs (ncRNAs) in the pathophysiology of mental diseases. As in-depth understanding of ncRNAs and their mechanisms of action, they have emerged as prospective diagnostic indicators and preclinical therapeutic targets for a variety of psychiatric illness, including AUD. Of note, dysregulated expression of ncRNAs such as circRNAs, lncRNAs and miRNAs was routinely found in AUD individuals, and besides, exogenous regulation of partial ncRNAs has also been shown to be effective in ameliorating alcohol preference and excessive alcohol consumption. However, the exact molecular mechanism still remains elusive. Herein, we systematically summarized current knowledge regarding alterations in the expression of certain ncRNAs as well as their-mediated regulatory mechanisms in individuals with AUD. And finally, we detailedly reviewed the potential theranostics applications of gene therapy agents targeting ncRNAs in AUD mice. Overall, a deeper comprehension of functional roles and biological mechanisms of ncRNAs may make significant contributions to the accurate diagnosis and effective treatment of AUD.

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“…The expression of striatal BDNF correlates with the expression of CREB, TrkB, and pri-miR-132 following amphetamine application in rats [ 236 ]. Heavy alcohol use causes upregulation of some miRNAs and consequently regulates BDNF values [ 237 ]. Adolescent intermittent ethanol exposure increased the miR-137 expression level in the amygdala.…”

Section: The Role Of Nts-mirna Interaction In Neuropsychological Diso...mentioning

confidence: 99%

A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders

et al. 2022

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Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies.

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Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use

Cited by 20 publications

References 87 publications

Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population

Altered Expression of Brain-specific Autism-Associated miRNAs in the Han Chinese Population

Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder

A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders

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