Differential control of β-endorphin/β-lipotropin secretion from anterior and intermediate lobes of the rat pituitary gland in vitro

Vermes, I.; Mulder, G.H.; Smelik, P. G.; Tilders, F. J. H.

doi:10.1016/0024-3205(80)90443-9

Cited by 138 publications

(62 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, histaminergic neurons, which originate exclusively in the posterior hypothalamus (1), seem to be involved in the mediation of stressinduced release of these hormones (2). Since HA does not appear to stimulate ACTH/b-endorphin (3,4) or prolactin secretion (5,6) directly at the pituitary level, its action may be indirect via activation of hypothalamic neurons, which subsequently release hypophysiotropic factors which stimulate pituitary hormone secretion. Corticotropin-releasing hormone (CRH) as well as arginine-vasopressin (AVP) and oxytocin (OT) are involved in regulation of ACTH and b-endorphin (7,8) secretion, and AVP and OT are also involved in control of prolactin secretion (9).…”

Section: Introductionmentioning

confidence: 99%

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

Kjær¹,

Larsen

Knigge³

et al. 1998

European Journal of Endocrinology

View full text Add to dashboard Cite

Centrally administered histamine (HA) stimulates the secretion of the pro-opiomelanocortin-derived peptides ACTH and b-endorphin as well as prolactin. The effect of HA on secretion of these adenohypophysial hormones is indirect and may involve activation of hypothalamic neurons containing corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) or oxytocin (OT).We studied the effect of activating central HA receptors by central infusion of HA, HA agonists or antagonists on expression of CRH, AVP and OT mRNA in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei.Intracerebroventricular infusion of HA (270 nmol), the H 1 -receptor agonist 2-thiazolylethylamine or the H 2 -receptor agonist 4-methylhistamine increased the level of CRH mRNA in the PVN, and OT mRNA in the SON. In contrast, none of these compounds had any effect on expression of AVP mRNA in the PVN or SON. Administration of the H 1 -receptor antagonist mepyramine or the H 2 -receptor antagonist cimetidine had no effect on basal expression of CRH, AVP or OT mRNA in the PVN and/or SON except for a slight inhibitory effect of cimetidine on CRH mRNA expression in the PVN. Pretreatment with mepyramine or cimetidine before HA administration inhibited the HA-induced increase in OT mRNA levels but had no effect on the HA-induced increase in CRH mRNA levels in the PVN.We conclude that HA stimulates hypothalamic CRH and OT neurons by increasing mRNA levels, and this effect seems to be mediated via activation of both HA H 1 and H 2 receptors.

show abstract

Section: Introductionmentioning

confidence: 99%

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

Kjær¹,

Larsen

Knigge³

et al. 1998

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…They suggested a participation of α-and β-adrenergic receptors in stimulation of β-END release from anterior and neurointermediate pituitary lobes, respectively. However, in the study of Vermes et al (1980) adrenergic factors did not affect β-END secretion by anterior pituitary cells of female rats. The action of adrenergic compounds on β-END secretion by neurointermediate lobe cells was confirmed in many studies (Vermes et al, 1980;Sweep and Wiegant, 1989;Némethy et al, 1998).…”

Section: The Effect Of Gnrh α-And β-Adrenergic Agents On β-End Secrementioning

confidence: 66%

“…However, in the study of Vermes et al (1980) adrenergic factors did not affect β-END secretion by anterior pituitary cells of female rats. The action of adrenergic compounds on β-END secretion by neurointermediate lobe cells was confirmed in many studies (Vermes et al, 1980;Sweep and Wiegant, 1989;Némethy et al, 1998). Overall, our results and the cited data -although divergent in several aspects -imply that numerous factors, including hormonal status of studied animals or experimental protocol (e.g.…”

Section: The Effect Of Gnrh α-And β-Adrenergic Agents On β-End Secrementioning

confidence: 66%

“…β-Adrenergic receptors have been detected in the anterior pituitary of rats (Denef and Baes, 1982;Perkins et al, 1985) and pigs (Perkins et al, 1985). It was also shown that stimulation of α-and β-adrenergic receptors by selective agonists induces release of pituitary β-END (Vermes et al, 1980;Berkenbosch et al, 1981;Pettibone and Mueller, 1982). Moreover, GnRH was found to stimulate differentiation of lactotrophs and to increase their number in the rat pituitary during postnatal period (Van Bael et al, 1994).…”

mentioning

confidence: 98%

“…Catecholamines and gonadotrophinreleasing hormone (GnRH) are other candidates, which may influence pituitary PRL and β-END secretion (Denef and Baes, 1982;Gambacciani et al, 1988;Kerdelhue et al, 1988;Shin and Barton, 1993;Denef, 1994;Colthorpe et al, 2000). Studies primarily performed on laboratory rodents have established that catecholamines are involved in the regulation of prolactin secretion (Vijayan and McCann, 1978;Weiner and Ganong, 1978;Deaver and Dailey, 1982) and β-END secretion (Vermes et al, 1980;Berkenbosch et al, 1981;Pettibone and Mueller, 1982). Besides acting at the level of hypothalamus, catecholamines can also directly influence the pituitary gland functions.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The effects of GnRH and adrenergic agents on PRL and ß-endorphin secretion by porcine pituitary cells in vitro

Siawrys

Bogacka

Okrasa

et al. 2003

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

The direct effects of α-and β-adrenergic agents on PRL and β-endorphin (β-END) secretion in vitro by porcine pituitary cells have been investigated. Pituitary glands were obtained from mature gilts, which were ovariectomised (OVX) one month before slaughter. Ovariectomised gilts, assigned to four groups, were primed with: (1) vehicle (OVX); (2) and (3) oestradiol benzoate (EB; 2.5 mg/100 kg b.w.) at 30-36 h (OVX+EB I) and 60-66 h (OVX+EB II) before slaughter, respectively; and (4) progesterone (P 4 ; 120 mg/100 kg b.w.) for 5 consecutive days before slaughter (OVX+P 4 ). Isolated anterior pituitary cells were submitted to 3.5 h incubation in the presence of GnRH, α-and β-adrenergic agonists [phenylephrine (PHEN) and isoproterenol (ISOP), respectively], or α-and β-adrenergic blockers [phentolamine (PHENT) and propranolol (PROP), respectively]. The culture media were assayed for PRL (exp. I) and β-endorphin-like immunoreactivity (β-END-LI) (experiment II). In experiment I, GnRH did not influence PRL release by pituitary cells in all experimental groups. Some of tested doses of adrenergic agonists, PHEN and ISOP, increased PRL release from pituitary cells of OVX gilts, but not from those of OVX+EB I animals. In the OVX+EB II group, PHEN alone, but ISOP with PROP, potentiated PRL secretion by the cells. In OVX+P 4 animals, PHEN alone or in combination with PHENT and also ISOP alone or with PROP enhanced PRL output from the cells. In experiment II, addition of GnRH increased β-END-LI release from pituitary cells only in the OVX+EB II group. PHEN and PHENT potentiated β-END-LI secretion by pituitary cells in OVX+EB II and OVX+P 4 groups, while ISOP and PROP increased β-END-LI secretion by the cells of OVX and OVX+EB II animals. In turn, in the OVX+EB I group, effect of PHENT and PROP on PRL secretion by pituitary cells was inhibitory. In conclusion, our results suggest that adrenergic agents can modulate PRL and β-END secretion by porcine pituitary cells in a manner dependent on the hormonal status of gilts.

show abstract

Natural Killer Cell Activity Reduced by Microwave Exposure during Pregnancy Is Mediated by Opioid Systems

Nakamura

Seto

Hatta

et al. 1998

Environmental Research

View full text Add to dashboard Cite

Differential control of β-endorphin/β-lipotropin secretion from anterior and intermediate lobes of the rat pituitary gland in vitro

Cited by 138 publications

References 21 publications

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors

The effects of GnRH and adrenergic agents on PRL and ß-endorphin secretion by porcine pituitary cells in vitro

Natural Killer Cell Activity Reduced by Microwave Exposure during Pregnancy Is Mediated by Opioid Systems

Contact Info

Product

Resources

About