“…Interestingly, these molecular pathways are reported in the placentas of PE patients [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. In addition, we found that TNF-α, MMP7, ADAMts5 mRNA levels were increased in the PE-like model, which is consistent with prior studies of human PE placentas where they are implicated to be involved in PE pathogenesis [ 15 , 16 , 17 , 18 ]. These results indicate that placental 11β-HSD2 is a key factor in PE development, and the 11β-HSD2 dysfunction-induced PE-like rat model resembles the characteristics of PE in humans.…”