Differential Characteristics of Skeletal Muscle in Community-Dwelling Older Adults

Yamada, Minoru; Kimura, Yosuke; Ishiyama, Daisuke; Nishio, Naohito; Abe, Yuki; Kakehi, Tomohiro; Fujimoto, Junko; Tanaka, Tomoya; Ohji, Shunsuke; Otobe, Yuhei; Koyama, Shingo; Okajima, Y; Arai, Hidenori

doi:10.1016/j.jamda.2017.05.011

Cited by 105 publications

(116 citation statements)

References 26 publications

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“…Our findings confirm and extend these observations in both the lower and upper extremities in adults ranging in age from 18 to 77 years with a commonly used sarcopenia diagnostic tool, DXA, to measure appendicular LST as the reference for muscle mass and both BIA‐phase angle and ultrasound echogenicity as two estimates of muscle quality. Our study and those of Yamada et al . and Taniguchi et al .…”

Section: Discussionsupporting

confidence: 90%

“…An important implication of our findings and those of Yamada et al ., Taniguchi et al ., and Tomerli et al . is that estimates of skeletal muscle mass can be augmented with BIA measurements when evaluating patients for the presence of sarcopenia and related functional limitations.…”

Section: Discussionsupporting

confidence: 68%

“…that included men and women with mean group ages in the seventh or eighth decades. Skeletal muscle mass or size was estimated in these studies using ultrasound or BIA prediction formulas . Phase angle was not specifically measured in these studies, rather quality indices calculated at different frequencies or predicted values for extracellular and intracellular water were derived from bioimpedance spectroscopy measurements .…”

Section: Discussionmentioning

confidence: 99%

“…Peak torque through extension was measured in Newton‐metres and taken as the maximum torque achieved during the three sets. We refer to this measurement as leg strength, although it has also been termed knee extension strength . The CV for leg strength measurements was 6.1%.…”

Section: Methodsmentioning

confidence: 99%

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Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Bourgeois

Fan

Johannsen

et al. 2018

J cachexia sarcopenia muscle

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Background Measures of skeletal muscle function decline at a faster rate with ageing than do indices of skeletal muscle mass. These observations have been attributed to age‐related changes in muscle quality, another functional determinant separate from skeletal muscle mass. This study tested the hypothesis that improved predictions of skeletal muscle strength can be accomplished by combining clinically available measures of skeletal muscle mass and quality. Methods The participants included 146 healthy adult (age ≥ 18 years, range 18–77 years; X ± SD 47 ± 17 years and body mass index 16.5–51.8 kg/m 2 ; 27.7 ± 6.2 kg/m 2 ) men ( n = 60) and women ( n = 86) in whom skeletal muscle mass was estimated as appendicular lean soft tissue (LST) measured by dual‐energy X‐ray absorptiometry and skeletal muscle quality as bioimpedance analysis‐derived phase angle and B‐mode‐evaluated echogenicity of mid‐thigh skeletal muscle. Strength of the right leg and both arms was quantified as knee isokinetic extension and handgrip strength using dynamometers. The statistical significance of adding phase angle or echogenicity to strength prediction multiple regression models that included extremity‐specific LST and other covariates (e.g. age and sex) was evaluated to test the study hypothesis. Results Right leg LST mass alone was significantly ( P < 0.0001) correlated with isokinetic right leg strength ( R 2 = 0.57). The addition of segmental phase angle measured in the right leg at 50 kHz increased the R 2 of this model to 0.66 ( P < 0.0001); other phase angle frequencies (5 and 250 kHz) did not contribute significantly to these models. Results were similar for both right and left arm handgrip strength prediction models. Adding age and sex as model covariates increased the R 2 values of these models further (e.g. right leg strength model R 2 increased to 0.71), but phase angle continued to remain a significant (all P < 0.01) predictor of extremity strength. Similarly, when predicting isokinetic right leg strength, mid‐thigh skeletal muscle echogenicity added significantly ( P < 0.0001) to right leg LST, increasing R 2 from 0.57 to 0.64; age was a significant ( P < 0.0001) covariate in this model, increasing R 2 further to 0.68. Conclusions The hypothesis of the current study was confirmed, strongly supporting and extending earlier reports by quantifying the combined independent effects of skeletal muscle mass and quality on lo...

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Bourgeois

Fan

Johannsen

et al. 2018

J cachexia sarcopenia muscle

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“…Echo intensity has been shown to serve as a useful index of intra-muscular fat; notably, Young et al 13 compared ultrasound echo intensity with high-resolution T1-weighted magnetic resonance imaging to establish calibration equations for estimation of the proportion of intra-muscular fat based on echo intensity. 30 The primary underlying factor in sarcopenia is ageing; previous studies have shown that echo intensity changes with age. The present study showed that good muscle quantity is correlated with good muscle quality in perioral muscle (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Tongue thickness is associated with masticatory performance of perioral muscles: Ultrasonographic study of perioral muscle characteristics in healthy young subjects

Yamaguchi

Tohara

Hara

et al. 2019

J of Oral Rehabilitation

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Background: Mastication is a complicated task that involves the teeth and perioral muscles, such as the tongue and lip. Previous studies have shown correlations between masticatory performance and perioral muscle strength (eg tongue pressure) and between masticatory performance and occlusal forces.Objective: To investigate the relationships between masticatory performance and perioral muscle characteristics.Methods: Forty-nine healthy young subjects (men: 24 and women: 25) with Eichner classification group A were included in this cross-sectional study. Age, body weight, masticatory performance, masseter muscle thickness, masseter muscle echo intensity, cross-sectional area of geniohyoid muscle, geniohyoid muscle echo intensity, tongue thickness (TT) and tongue echo intensity were assessed. Masticatory performance was evaluated using a colour-changeable chewing gum. The thickness and echo intensity of the masseter muscle, geniohyoid muscle and tongue were observed using an ultrasonic diagnostic apparatus. Stepwise multiple regression analysis was conducted to examine relationships between perioral muscle characteristics and masticatory performance.Results: Tongue thickness (P < .01) was the sole significant explanatory variable for masticatory performance. The standard partial regression coefficient was 0.47. The multiple correlation coefficient (R) was .47, and the adjusted R 2 was .20; the variance inflation factor was 1.0. This study showed that TT was related to masticatory performance, whereas perioral muscle quality was not. Moreover, perioral muscle quantity was highly correlated with perioral muscle quality. Conclusions:Tongue thickness is a predictor of masticatory performance in healthy young subjects. An ultrasonic diagnostic apparatus is useful in the evaluation of perioral muscle characteristics. K E Y W O R D Schewing gum, masseter muscle, mastication, masticatory muscles, tongue, ultrasonography cross-sectional studies

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Relationships between cystatin C and creatinine‐based eGFR with low tongue pressure in Japanese rural community‐dwelling older adults

Kusunoki

Hirabayashi

Tsuji

et al. 2022

Clinical & Exp Dental Res

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Background: Sarcopenia is prevalent in patients with chronic kidney disease (CKD), which is defined as a low estimated glomerular filtration rate (eGFR). It has been reported that oral hypofunction characterized by decreased tongue pressure is related to sarcopenia. Although there are several previous reports regarding the association of renal dysfunction with oral hypofunction characterized by low tongue pressure, the association between tongue pressure and renal function is not fully understood. Methods: This cross-sectional study included 68 men aged 79.0 ± 4.8 years and 145 women aged 77.3 ± 5.4 years from a rural area in Hyogo Prefecture, Japan. We examined the relationships between cystatin C-based CKD (CKDcys), creatininebased CKD (CKDcre), ratio of cystatin C-based GFR (eGFRcys) divided by creatininebased GFR (eGFRcre): eGFRcys/eGFRcre, and tongue pressure in communitydwelling older adults.Results: Tongue pressure was significantly lower in participants with CKDcys than in those without CKDcys in men and women. However, there were no significant differences in tongue pressure with or without CKDcre. Tongue pressure was significantly lower in participants with eGFRcys/eGFRcre <1.0, than in those with eGFRcys/eGFRcre ≧ 1.0 in men. According to the receiver operating characteristic analysis, the optimal cut-off value of tongue pressure for the presence of CKDcys was 36.6kPa, area under the curve (AUC) 0.74 (specificity 54.8%, sensitivity 84.6%) in men and 31.8kPa, AUC 0.65 (specificity 67.3%, sensitivity 60.5%) in women.Conclusions: CKDcys but not CKDcre is associated with low tongue pressure. In addition, a lower eGFRcys/eGFRcre ratio is a useful screening marker of low tongue pressure in community-dwelling older adults.

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Differential Characteristics of Skeletal Muscle in Community-Dwelling Older Adults

Cited by 105 publications

References 26 publications

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Tongue thickness is associated with masticatory performance of perioral muscles: Ultrasonographic study of perioral muscle characteristics in healthy young subjects

Relationships between cystatin C and creatinine‐based eGFR with low tongue pressure in Japanese rural community‐dwelling older adults

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