Differential changes in sympathetic activity in left and right ventricles in congestive heart failure after myocardial infarction

Ganguly, Pallab K.; Dhalla, Ken S.; Shao, Qiming; Beamish, Robert E.; Dhalla, Naranjan S.

doi:10.1016/s0002-8703(97)70230-8

Cited by 34 publications

(31 citation statements)

References 16 publications

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“…An interesting finding is the difference in NA concentration between left and right ventricle in the saline group. This finding has also been reported by Ganguly et al and interpreted as a consequence of different changes in sympathetic activity in left and right ventricles during development of CHF (29). This was not observed in the metoprolol group suggesting that adrenergic drive in LV was suppressed.…”

Section: Discussionsupporting

confidence: 89%

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Selective β1-Blockade Improves Cardiac Bioenergetics and Function and Decreases Neuroendocrine Activation in Rats during Early Postinfarct Remodeling

Ömerovic

Bollano

Mobini

et al. 2001

Biochemical and Biophysical Research Communications

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Section: Discussionsupporting

confidence: 89%

“…Lower levels of plasma catecholamines and BNP are also evidence for functional improvement in this group. Results from large number of experimental and clinical studies have consistently documented improvement in cardiac function after at least 1 month therapy with ␤-blockade (29).…”

Section: Discussionmentioning

confidence: 99%

Selective β1-Blockade Improves Cardiac Bioenergetics and Function and Decreases Neuroendocrine Activation in Rats during Early Postinfarct Remodeling

Ömerovic

Bollano

Mobini

et al. 2001

Biochemical and Biophysical Research Communications

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“…7) The damaged heart muscle is unable to maintain normal blood circulation through the body. The blood flow from the heart is reduced and backs up through the vein causing congestion in the tissues.…”

Section: Resultsmentioning

confidence: 99%

Beneficial Effect of Portacaval Shunt on Cardiac Contractility in Dogs.

Ganguly

2001

JOURNAL OF HEALTH SCIENCE

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Despite advances in cardiovascular medicine, the endogenous mechanisms responsible for positive inotropic state of the heart is poorly understood. We have assessed surgical transposition of the portal vein (portacaval shunt) as a procedure providing total systemic delivery of portal venous effluent in six dogs. The animals recovered rapidly from the surgery maintaining euglycemia. Four days after surgery the serum enzymes such as alkaline phosphatase, alanine aminotransferase and gamma glutamyl transferase returned to normal values, whereas all the animals had significantly higher values of urine volume and left ventricular dP/dt. Pre and postoperative left ventricular pressure was unchanged. Our results indicate that portacaval shunt plays an endogenous role in the positive inotropic state of the heart, and suggest that this surgical procedure may provide an insight into its beneficial role in heart failure.Key words ---Portacaval shunt, myocardial contractility, plasma insulin, heart failure INTRODUCTIONThe gut has many peptides which play a major role in cardiac physiology.1,2) However, the functions of the gut peptides are limited by their entry into the liver, which plays a crucial role in metabolism. Their systemic effects thus may be compromised, confounding interpretation. With systemic diversion of portal venous effluent achieved by endto-side portacaval anastomosis, gut peptides including pancreatic hormones can directly act on cardiac muscle and can enhance the inotropic state of the heart.3) Accordingly, the experiments were carried out to examine the effect of portacaval shunt on cardiac contractility in dogs. As a preliminary study, the experiments were restricted to the control animals and the various parameters of the pre and postoperative surgery were compared. Our results suggest that portacaval shunt plays an endogenous role in the positive inotropic state of the heart. MATERIAL AND METHODSAnimals and Operation ---Six mongrel dogs weighing 16-20 kg were used in this study. The animals were sedated with xylazine (0.3 mg/kg, im). General anesthesia was maintained with halothane (1.0-2.0 vol/100 ml in O 2 ). The dogs were ventilated with a respirator and laporatomy was performed. An end-to-side portacaval shunt was carried out in each dog as described previously.4) The dogs were given standard medical therapy with i.v. glucose and fluids and were observed and monitored in their cages with frequent measurements of hematological and biochemical parameters for four days. Assay ---Blood alkaline phosphatase, alanine aminotransferase, gamma glutamyl transferase and bilirubin were measured by computer-assisted vet scan (California, U.S.A.). The hemodynamic data were recorded on a direct-writing oscillograph. Left ventricular pressure and dP/dt were obtained as described earlier.5) Insulin and glucagon were measured by radioimmunoassay. RESULTS AND DISCUSSIONThe effect of portacaval shunt on blood biochemistry is shown in Tables 1 and 2. Table 1 shows the effect of portacaval shunt on the blood level of...

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“…In central nervous system (CNS), the neurotransmission of NE is terminated through reuptake of released neurotransmitter by Na + , Cl -dependent norepinephrine transporter (NET) on pre-synaptic membrane [1], [2]. Although the NE uptake was well studied in heart, but the molecular basis for that is still less clear [3][4][5]. Ungerer et.al indicated that they could not detect any specific mRNA of NET in the myocardium investigated [6].…”

Section: Introductionmentioning

confidence: 99%

Norepinephrine transporter (NET) is expressed in cardiac sympathetic ganglia of adult rat

Sun

et al. 2001

Cell Res

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The sympathetic nervous system plays a cardinal role in regulating cardiac function through releasing the neurotransmitter norepinephrine (NE). In comparison with central nervous system, the molecular mechanism of NE uptake in myocardium is not clear. In present study, we proved that in rat the CNS type of NE transporter (NET) was also expressed in middle cervical-stellate ganglion complex (MC-SG complex) which is considered to control the activity of heart, but not expressed in myocardium. The results also showed that NET expression level in right ganglion was significantly higher than in the left, rendering the greater capacity of NE uptake in right ventricle, a fact which may contribute to the maintenance of right ventricular function under pathologic state.

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Differential changes in sympathetic activity in left and right ventricles in congestive heart failure after myocardial infarction

Cited by 34 publications

References 16 publications

Selective β1-Blockade Improves Cardiac Bioenergetics and Function and Decreases Neuroendocrine Activation in Rats during Early Postinfarct Remodeling

Selective β1-Blockade Improves Cardiac Bioenergetics and Function and Decreases Neuroendocrine Activation in Rats during Early Postinfarct Remodeling

Beneficial Effect of Portacaval Shunt on Cardiac Contractility in Dogs.

Norepinephrine transporter (NET) is expressed in cardiac sympathetic ganglia of adult rat

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