“…Nevertheless, sudden cardiac deaths, though uncommon, have been associated with long-term treatment with older as well as modern antipsychotic drugs, and unanticipated cardiac arrhythmias may contribute to this risk [ 99,140,171,172 ] ; decreased mortality also has been reported in association with long-term antipsychotic treatment [ 206 ] . Prolongation of the QTc interval is especially likely with thioridazine or mesoridazine more than haloperidol among older neuroleptics, somewhat less with ziprasidone, and apparently negligibly with clozapine among second-generation antipsychotics [ 4,26,81 ] . Taken alone, short of severe acute overdoses, such responses to these agents are not likely, but risk increases as additional agents with inhibitory effects on cardiac repolarization are added, including tricyclic antidepressants and class Ia, sodium-channel blocking, antiarrhythmic drugs such as quinidine, procainamide (Pronestyl ® ), and disopyramide (Norpace ® ), or if other risk factors are present.…”