“…In this study, we focused on an important epigenetic modifier, PRMT7, whose physiologic roles have been established in male imprinted gene methylation, mRNA splicing, DNA repair, and neural cell differentiation (17,(20)(21)(22). To date, PRMT7 has not been studied in association with cancer progression, although other members of the PRMT family, such as PRMT1, PRMT4/CARM1, PRMT5 and PRMT6, have been found to be either upregulated or downregulated in prostate cancer, breast cancer, colon carcinoma, and melanoma (36)(37)(38)(39). Data arising from this study unraveled, for the first time, the functional role of PRMT7 in regulating the EMT in breast cancer.…”