Differential brain processing of audiovisual sexual stimuli in men: Comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal

Miyagawa, Yasushi; Tsujimura, Akira; Fujita, Kazutoshi; Matsuoka, Yoshikazu; Takahashi, Tohru; Takao, Tetsuya; Takada, Shingo; Matsumiya, Kiyomi; Osaki, Yasuhiro; Takasawa, Masashi; Oku, Naohiko; Hatazawa, Jun; Kaneko, Shigeo; Okuyama, Äkïhïko

doi:10.1016/j.neuroimage.2007.03.055

Cited by 53 publications

(41 citation statements)

References 64 publications

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“…However, physiological and behavioral differences between animals and humans make it difficult to directly apply the results to humans. Of the few Effect of SSRI on EEG of premature ejaculation patients OY Kwon et al studies in humans, most have used PET or functional magnetic resonance imaging, [17][18][19] measuring changes in cerebral blood flow or changes in oxygen concentration in blood flow to indirectly reflect neuronal activity. These methods are widely accepted, but their limitations must be considered.…”

Section: Discussionmentioning

confidence: 99%

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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To identify the effects of sertraline, a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation (PE), changes in brain current-source density (CSD) of the high beta frequency band (22-30 Hz) induced by sertraline administration were investigated during audiovisual erotic stimulation. Eleven patients with PE (36.9 ± 7.8 yrs) and 11 male volunteers (24.2 ± 1.9 years) were enrolled. Scalp electroencephalography (EEG) was conducted twice: once before sertraline administration and then again 4 h after the administration of 50 mg sertraline. Statistical nonparametric maps were obtained using the EEG segments to detect the current-density differences in the high beta frequency bands (beta-3, 22-30 Hz) between the EEGs before and after sertraline administration in the patient group and between the patient group and controls after the administration of sertraline during the erotic video sessions. Comparing between before and after sertraline administration in the patients with PE, the CSD of the high beta frequency band at 4 h after sertraline administration increased significantly in both superior frontal gyri and the right medial frontal gyrus (Po0.01). The CSD of the beta-3 band of the patients with PE were less activated significantly in the middle and superior temporal gyrus, lingual and fusiform gyrus, inferior occipital gyrus and cuneus of the right cerebral hemisphere compared with the normal volunteers 4 h after sertraline administration (Po0.01). In conclusion, sertraline administration increased the CSD in both the superior frontal and right middle temporal gyrus in patients with PE. The results suggest that the increased neural activity in these particular cerebral regions after sertraline administration may be associated with inhibitory effects on ejaculation in patients with PE.

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Section: Discussionmentioning

confidence: 99%

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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“…Activation maps highlighted a complex neural circuit involved in sexual arousal. Of this circuit, only a few areas (anterior cingulate, insula, amygdala, hypothalamus, and secondary somatosensory cortices) were specifically correlated with penile erection (Ferretti et al, 2005;Miyagawa et al, 2007). Further research in these fields is needed and may be rewarding.…”

Section: Central Regulationmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…Finally, not only does the cerebral cortex show sexual lateralization but also other cerebral subcortical structures involved in sexuality, such as the hypothalamus, the ventral putamen, anterior cingulate, and insula (Miyagawa et al, 2007). Further studies are necessary to deepen the study of cognitive and sexual lateralization, with sexual hormones included as relevant factors that influence morphological, physiological, and functional asymmetries within the brain (Wisniewski, 1998).…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on Tamoxifen Sexual Side Effects and Hand Preference in Male Breast Cancer

et al. 2015

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Recent clinical and imaging studies suggest that sex hormones modulate sexuality according to a psychophysiologic process of lateralization of the brain, with androgens playing a greater role in sexual functioning of left hemibrain/right handedness and estrogens possibly for right hemibrain/left handedness. Based on this perspective, the current study attempted to specify the relationship between hand preference, estrogens, and sexual function in subjects with male breast cancer, taking into account the sexual side effects of tamoxifen as the agent for inhibiting estrogen action. Twenty-eight Romanian men-17 right-handed and 11 left-handed-undergoing treatment with tamoxifen for male breast cancer participated in this study. These men were assessed both prior to and during tamoxifen treatment using the International Index of Erectile Function, a standardized instrument used for the evaluation of various aspects of sexual functioning, including erectile function (EF), orgasmic function (OF), sexual desire (SD), and overall functioning (OF). A main effect for handedness was found on EF, OF, SD, and OS scales, with right-handed men showing higher functioning than left-handed men. Regarding interaction effects, the left-handed group of men showed greater decreased sexual functioning during tamoxifen (on three subscales: OF, SD, OS) compared to right-handed men. Further research should be conducted in order to support and refine this potential lateralized process of sexual neuromodulation within the brain.

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Differential brain processing of audiovisual sexual stimuli in men: Comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal

Cited by 53 publications

References 64 publications

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

A Pilot Study on Tamoxifen Sexual Side Effects and Hand Preference in Male Breast Cancer

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