1979
DOI: 10.1016/0006-291x(79)90601-6
|View full text |Cite
|
Sign up to set email alerts
|

Differential binding of antiestrogens by rat uterine and chick oviduct cytosol

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
21
0

Year Published

1983
1983
2008
2008

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 80 publications
(24 citation statements)
references
References 12 publications
3
21
0
Order By: Relevance
“…The authors suggest that the concentration of free (tamoxifen) ligand is reduced such that secondary binding is not achievable, hence the sole agonist action. Similar observations have been made, for example, in cytosol extracts from chick oviduct (Sutherland & Foo 1979, Sutherland et al 1980, mature rat uterus (Faye et al 1980, Sutherland et al 1980, immature rat uterus (Sutherland et al 1980, Murphy & Sutherland 1981a, rat liver , 1986, van den Koedijk et al 1992, rat serum , guinea pig uterus (Gulino & Pasqualini 1980), calf uterus (Lerea et al 1987, ER-positive human breast carcinomas (Sutherland et al 1980, Jordan et al 1981, Murphy & Sutherland 1981a,b, Watts et al 1984, Berthois et al 1994, human follicular thyroid carcinoma cells (Gross et al 1993), and human endometrium (Sutherland et al 1980). In these tissues, a biomacromolecule was observed to bind tamoxifen and other estrogenic derivatives, including ICI 47699 (Murphy & Sutherland 1981a), and displays tissue-specific differences in cellular concentration .…”
Section: Biochemical History Of the Dual Agonist/ Antagonist Activitysupporting
confidence: 84%
“…The authors suggest that the concentration of free (tamoxifen) ligand is reduced such that secondary binding is not achievable, hence the sole agonist action. Similar observations have been made, for example, in cytosol extracts from chick oviduct (Sutherland & Foo 1979, Sutherland et al 1980, mature rat uterus (Faye et al 1980, Sutherland et al 1980, immature rat uterus (Sutherland et al 1980, Murphy & Sutherland 1981a, rat liver , 1986, van den Koedijk et al 1992, rat serum , guinea pig uterus (Gulino & Pasqualini 1980), calf uterus (Lerea et al 1987, ER-positive human breast carcinomas (Sutherland et al 1980, Jordan et al 1981, Murphy & Sutherland 1981a,b, Watts et al 1984, Berthois et al 1994, human follicular thyroid carcinoma cells (Gross et al 1993), and human endometrium (Sutherland et al 1980). In these tissues, a biomacromolecule was observed to bind tamoxifen and other estrogenic derivatives, including ICI 47699 (Murphy & Sutherland 1981a), and displays tissue-specific differences in cellular concentration .…”
Section: Biochemical History Of the Dual Agonist/ Antagonist Activitysupporting
confidence: 84%
“…The ALBS is a member of the family of high affinity membrane-associated binding sites called anti-estrogen binding sites or AEBS (Sutherland & Foo 1979, Sutherland et al 1980) which have been identified in a variety of tissues (Gulino & Pasqualini 1982, Mehta et al 1984. A TAM resistant clone of MCF-7 cells, RTx6, differs from the parent MCF-7 cells in having no AEBS, but is identical to the parent cells with respect to the ER content and affinity (Faye et al 1987).…”
Section: The Anti-lactogen Binding Site (Albs)mentioning
confidence: 99%
“…These include: muscarinic receptors (Ben-Baruch et al, 1982), dopamine receptors (Hiemke & Ghraf, 1984), histamine receptors (Brandes et al, 1985), cytochromes P-450 (Ruenitz et al, 1984), calmodulin (Lam, 1984), protein kinase C (O'Brian et al, 1985) and a high affinity binding site of unknown function termed the antioestrogen binding site (AEBS) (Sutherland & Foo, 1979;Sutherland et al, 1980). The roles, if any, of these binding sites in mediating any of the effects of nonsteroidal antioestrogens, in particular their apparently non-oestrogen-receptor-mediated effects, have not been directly established, although workers in this laboratory have shown that analogues with high affinity for AEBS have more potent antiproliferative effects on breast cancer cells in vitro than analogues with low affinity for AEBS , 1985.…”
Section: Introductionmentioning
confidence: 99%