Differential binding between volatile ligands and major urinary proteins due to genetic variation in mice

Kwak, Jae; Grigsby, Claude C.; Rizki, Mateen M.; Preti, George; Koksal, M.; Josue, Jesusa; Yamazaki, Kunio; Beauchamp, Gary K.

doi:10.1016/j.physbeh.2012.06.008

Cited by 57 publications

(57 citation statements)

References 51 publications

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“…ref. 36) or as differences in the profile of volatiles bound and released from the central cavities of MUPs52646566. The cavity residues of central MUPs are highly conserved, with only one out of 20 residues showing variation.…”

Section: Discussionmentioning

confidence: 99%

Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation

Hurst

Beynon

Armstrong

et al. 2017

Sci Rep

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When hybridisation carries a cost, natural selection is predicted to favour evolution of traits that allow assortative mating (reinforcement). Incipient speciation between the two European house mouse subspecies, Mus musculus domesticus and M.m.musculus, sharing a hybrid zone, provides an opportunity to understand evolution of assortative mating at a molecular level. Mouse urine odours allow subspecific mate discrimination, with assortative preferences evident in the hybrid zone but not in allopatry. Here we assess the potential of MUPs (major urinary proteins) as candidates for signal divergence by comparing MUP expression in urine samples from the Danish hybrid zone border (contact) and from allopatric populations. Mass spectrometric characterisation identified novel MUPs in both subspecies involving mostly new combinations of amino acid changes previously observed in M.m.domesticus. The subspecies expressed distinct MUP signatures, with most MUPs expressed by only one subspecies. Expression of at least eight MUPs showed significant subspecies divergence both in allopatry and contact zone. Another seven MUPs showed divergence in expression between the subspecies only in the contact zone, consistent with divergence by reinforcement. These proteins are candidates for the semiochemical barrier to hybridisation, providing an opportunity to characterise the nature and evolution of a putative species recognition signal.

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Section: Discussionmentioning

confidence: 99%

Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation

Hurst

Beynon

Armstrong

et al. 2017

Sci Rep

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“…Pheromone binding by MUPs was proposed to prevent pheromone degradation or evaporation from scent marks or to escort pheromones to hydrophilic environments such as urine or the VNO lumen. However, MUPs encoded by different genes or individuals display largely similar binding preferences for urinary volatiles (104, 105), raising the question of why so many MUPs are needed if they function only as pheromone chaperones.…”

Section: Chemical Diversity Of Mammalian Pheromonesmentioning

confidence: 99%

Mammalian Pheromones

Liberles

2014

Annu. Rev. Physiol.

250

246

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Mammalian pheromones control a myriad of innate social behaviors and acutely regulate hormone levels. Responses to pheromones are highly robust, reproducible, and stereotyped and likely involve developmentally predetermined neural circuits. Here, I review several facets of pheromone transduction in mammals, including (a) chemosensory receptors and signaling components of the main olfactory epithelium and vomeronasal organ involved in pheromone detection; (b) pheromone-activated neural circuits subject to sex-specific and state-dependent modulation; and (c) the striking chemical diversity of mammalian pheromones, which range from small, volatile molecules and sulfated steroids to large families of proteins. Finally, I review (d ) molecular mechanisms underlying various behavioral and endocrine responses, including modulation of puberty and estrous; control of reproduction, aggression, suckling, and parental behaviors; individual recognition; and distinguishing of own species from predators, competitors, and prey. Deconstruction of pheromone transduction mechanisms provides a critical foundation for understanding how odor response pathways generate instinctive behaviors.

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“…In the house mouse, unrelated individuals tend to have different combinations of these MUPs, in ways as diverse as the major histocompatibility complex (MHC; Hurst & Beynon, 2013). MUPs differing in the amino acid sequences of the hydrophobic cavity bind small ligands with different affinities (Kwak et al, 2012). Thus the individual MUP profile of an animal influences its chemical profile of volatiles.…”

Section: Proteins Providing Slow Release Of Small Volatile Moleculesmentioning

confidence: 99%

Proteins and peptides as pheromone signals and chemical signatures

Wyatt

2014

Animal Behaviour

110

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Differential binding between volatile ligands and major urinary proteins due to genetic variation in mice

Cited by 57 publications

References 51 publications

Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation

Molecular heterogeneity in major urinary proteins of Mus musculus subspecies: potential candidates involved in speciation

Mammalian Pheromones

Proteins and peptides as pheromone signals and chemical signatures

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