Differential Behavior of Serum and Red Blood Cell Folate During a Treatment with Levofolinic Acid. Gender Differences

Am, Lendinez; Ar, Palomares; Pérez-Nevot, Beatriz; M, Cortés Rodríuez; Ruiz-Galdón, Maximiliano; Reyes‐Engel, Armando

doi:10.7754/clin.lab.2013.130914

Cited by 2 publications

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“…In this study, we found that Hcy level was higher in male than it was in female, and not only in patients with MSA, but in controls, too. This verified the views that the lack of estrogen can cause an increase in the level of Hcy, and the folate metabolism is different between individuals of different sex [ 24 ]. Environmental factors such as excessive coffee or alcohol intake, smoking, or physical inactivity may increase the plasma levels of Hcy [ 25 ].…”

Section: Discussionsupporting

confidence: 82%

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study

et al. 2015

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BackgroundMultiple system atrophy (MSA) is a neurodegenerative disease, and its pathological hallmark is the accumulation of α-synuclein proteins. Homocysteine (Hcy) is an intermediate amino acid generated during the metabolism of methionine. Hcy may contribute to the pathogenesis of neurodegenerative disorders. Vitamin B12 and folate are cofactors necessary for the methylation of homocysteine.MethodsThis study compared the levels of serum Hcy, vitamin B12 and folate in patients with MSA with those in healthy people to reveal the possible association between MSA and plasma levels of Hcy, vitamin B12 and folate. We enrolled 161 patients with MSA and 161 healthy people in this study. The association between MSA and the levels of Hcy, vitamin B12 and folate were analyzed using binary logistic regression.ResultsThe mean level of Hcy in patients with MSA was significantly higher than that in healthy controls (16.23 ± 8.09 umol/l vs 14.04 ± 4.25 umol/l, p < 0.05). After adjusting for age, sex and medical history, the odds ratio for Hcy was 1.07 (95% CI = 1.01–1.13, p < 0.05) for patients with MSA. Vitamin B12 and folate levels were not significantly different between patients with MSA and controls.ConclusionOur data suggest that higher levels of Hcy may be associated with an increased risk for MSA.

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Section: Discussionsupporting

confidence: 82%

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study

et al. 2015

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“…The addition of folic acid fortification in the diet of pregnant women drastically reduced the incidence of NTD in newborns, leading to different public health agencies worldwide recommending it for use in pregnant women [ 7 , 8 ]. As is routine during IVF treatments, patients are recommended to have folic acid supplies even before the initiation of the treatment, so the prevention is presumably reached, especially considering that Hcy levels are normalized in approximately 10 days [ 9 ]. FOCM disruption can also be due to gene variants affecting key enzymes, such as those concerning the MTHFR gene with strong influence on reproduction and embryo viability [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification

Palomares

Ruiz-Galdón

Liu

et al. 2022

IJMS

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Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts nucleotide synthesis and methylation, which is of increasing interest in the reproductive medicine field. Studies assessing the genetic influence of folate metabolism on IVF treatments have currently been performed in women using their own oocytes. Most of these patients seeking to have a child or undergoing IVF treatments are advised to preventively intake folate supplies that restore known metabolic imbalances, but the treatments could lead to the promotion of specific enzymes in specific women, depending on their genetic variance. In the present study, we assess the influence of candidate gene variants related to folate metabolism, such as Serine Hydroxymethyltransferase 1 SHMT1 (rs1979276 and rs1979277), Betaine-Homocysteine S-Methyltransferase BHMT (rs3733890), Methionine synthase reductase MTRR (rs1801394), Methylenetetrahydrofolate reductase MTHFR (rs1801131 and rs1801133), methionine synthase MTR (rs12749581), ATP Binding Cassette Subfamily B Member 1 ABCB1 (rs1045642) and folate receptor alpha FOLR1 (rs2071010) on the success of IVF treatment performed in women being recipients of donated oocytes. The implication of such gene variants seems to have no direct impact on pregnancy consecution after IVF; however, several gene variants could influence pregnancy loss events or pregnancy maintenance, as consequence of folic acid fortification.

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Differential Behavior of Serum and Red Blood Cell Folate During a Treatment with Levofolinic Acid. Gender Differences

Cited by 2 publications

References 0 publications

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study

Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification

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