Differential aversive effects of mesencephalic central gray stimulation in two inbred strains of mice

Cazala, Pierre; Garrigues, Anne-Marie

doi:10.1016/s0163-1047(81)90362-9

Behavioral and Neural Biology

1981

DOI: 10.1016/s0163-1047(81)90362-9

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Differential aversive effects of mesencephalic central gray stimulation in two inbred strains of mice

Pierre Cazala

Anne-Marie Garrigues

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1983

1991

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Cited by 9 publications

(3 citation statements)

References 12 publications

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“…It is known that the mesencephalon or the periventricular system respectively plays an important role in the integration of aversion in animals (1)(2)(3)(4). Stimulation of the mesencephalic dorsal part of the central gray (DCG) caused strong behavior indicating averse sensation, such as jumping, running and escape behavior (2)(3)(4).…”

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confidence: 99%

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Differential effects of morphine on operant escape behavior and averse symptom induced by dorsal central gray stimulation in rats.

Moriyama

Gomita

Ichimaru³

et al. 1991

Jpn.J.Pharmacol

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ABSTRACT-The involvement of a central opiate mechanism in the operant escape behavior induced by dorsal central gray (DCG) stimulation was investigated in rats. Morphine (2-10 mg/kg, i.p.) produced a rise in the DCG-stimulation threshold, but did not suppress rapid running as an averse symptom. Naloxone alone affected neither the threshold nor the averse symptom. Nevertheless, naloxone counteracted morphine-induced increments in the threshold. These results suggest that the opiate system may be indirectly involved in certain aspects of the operant escape behavior induced by the DCG-stimulation.It is known that the mesencephalon or the periventricular system respectively plays an important role in the integration of aversion in animals (1-4). Stimulation of the mesencephalic dorsal part of the central gray (DCG) caused strong behavior indicating averse sensation, such as jumping, running and escape behavior (2-4). The animals learn to stop the DCG stimulation in an operant situation (operant escape response). As to the involvement of endogenous amines of the brain in this behavior, Kiser et al. (5) showed that the averse behavior induced by DCG-stimulation was affected by the manipulation of brain serotonin function. Cazala and Garrigues (4) reported that 5-methoxy-N,N-dimethyl-tryptamine decreased the latency time of the escape response induced by the DCG-stimulation in mice. In addition, our previous study showed that the DCG-stimulation threshold for induction of the escape response was increased by 5-hydroxytryptophan (5-HTP) and chlorimipramine, and it was decreased by p-chlorophenylalanine (PCPA) and cyproheptadine (6). Furthermore, we have observed that cholinergic drugs such as physostigmine and arecoline caused an increase of the stimulation threshold, and anticholinergic drugs such as scopolamine and atropine caused a decrease of the threshold (7). These findings indicate that the operant escape behavior induced by the DCG-stimulation is related not only to the central serotonergic mechanism but also to a cholinergic mechanism.On the other hand, as to the involvement of the opiate mechanism on mesencephalic stimulation, Kiser et al. (8) and Schmitt et al. (9) observed that latencies of escape behavior induced by DCG-stimulation were increased by electrical stimulation of the dorsal raphe nuclei which contain some serotonergic cells. Kiser and German (10) suggested that serotonin suppresses the susceptibility to foot-shock

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mentioning

confidence: 99%

“…Stimulation of the mesencephalic dorsal part of the central gray (DCG) caused strong behavior indicating averse sensation, such as jumping, running and escape behavior (2)(3)(4). The animals learn to stop the DCG stimulation in an operant situation (operant escape response).…”

mentioning

confidence: 99%

Differential effects of morphine on operant escape behavior and averse symptom induced by dorsal central gray stimulation in rats.

Moriyama

Gomita

Ichimaru³

et al. 1991

Jpn.J.Pharmacol

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“…A number of investigators have shown that the electrical stimulation of the mesence phalon or periventricular system produces aversive operant behavior and/or fear responses in rats, cats and mice (1)(2)(3)(4)(5)(6). It is known that the stimulation applied to the dorsal part of the central gray (DCG) has strong aversive characteristics and also caused the increase of arterial blood pressure, heart rate and respiration in the rat (7).…”

mentioning

confidence: 99%

Effects of Cholinergic Drugs on Aversive Operant Behavior Induced by Dorsal Central Gray Stimulation in Rats

Moriyama

Ichimaru

Gomita

et al. 1985

Japanese Journal of Pharmacology

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Abstract-Involvement of a central cholinergic mechanism in the central aversive operant behavior induced by dorsal central gray (DCG) stimulation was investigated in rats. Each animal was chronically implanted with bipolar electrodes at the DCG and was trained to press a lever to decrease the DCG-stimulation current. Physostigmine (0.1 and 0.2 mg/kg, i.p.) and arecholine (0.5-2.0 mg/kg, i.p.) produced an increase of DCG-stimulation threshold at 0.5-2 hr and 1-4 hr, respectively, after the administration.On the other hand, scopolamine (0.1-0.5 mg/ kg, i.p.) and atropine (5 and 10 mg/kg, i.p.) caused a marked decrease of the threshold at 0.5-2 hr after. In addition, an increasing effect of physostigmine on the threshold was decreased by scopolamine. Physostigmine potentiated the increasing effect of chlorimipramine on the stimulation threshold, while scopolamine suppressed it. These results suggest that the operant behavior induced by DCGstimulation may be related to not only the central serotonergic mechanism but also to the cholinergic mechanism.

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A Y-maze test reveals the positively reinforcing properties of electrical stimulation of the mesencephalic central gray area

Cazala

Zielinski

1983

Brain Research

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Differential aversive effects of mesencephalic central gray stimulation in two inbred strains of mice

Cited by 9 publications

References 12 publications

Differential effects of morphine on operant escape behavior and averse symptom induced by dorsal central gray stimulation in rats.

Differential effects of morphine on operant escape behavior and averse symptom induced by dorsal central gray stimulation in rats.

Effects of Cholinergic Drugs on Aversive Operant Behavior Induced by Dorsal Central Gray Stimulation in Rats

A Y-maze test reveals the positively reinforcing properties of electrical stimulation of the mesencephalic central gray area

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