Differential attenuation of some effects of haloperidol in rats given scopolamine

Setler, Paulette E.; Sarau, Henry M.; McKenzie, Gerald M.

doi:10.1016/0014-2999(76)90119-9

Cited by 110 publications

(25 citation statements)

References 18 publications

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“…There is evidence to suggest that CAR is mediated primarily via DA mesocorticolimbic pathways involving the ventral striatum (Wadenberg et al 1990), while catalepsy is considered an effect primarily of D 2 receptor blockade in the caudate putamen regions (dorsal striatum) of the DA nigrostriatal pathway (Calderon et al 1988;Hauber and Munkle 1997). Second, anticholinergic agents, while completely reversing catalepsy, have minimal or no effect on the CAR model (Setler et al 1976) suggesting a functional dissociation between these two models. Finally, a selective dose of a 5-HT 1A agonist facilitates suppression of the CAR, while at the same time it antagonizes the effects on catalepsy, thus providing a double dissociation (Wadenberg and Ahlenius 1991).…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Occupancy Is a Common Mechanism Underlying Animal Models of Antipsychotics and Their Clinical Effects

Wadenberg

Soliman

VanderSpek

et al. 2001

Neuropsychopharmacology

223

167

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Conditioned avoidance response (CAR) behavior and catalepsy (CAT) are the standard preclinical tests used to predict antipsychotic activity and motor side-effect liability, respectively. Recent data in patients showUsing this technique, Farde et al. (1992) suggested that both antipsychotic response and extrapyramidal side effects (EPS) may be related to D 2 receptor occupancyalbeit with different thresholds. With typical antipsychotics, a D 2 receptor occupancy in the range of 70% was associated with clinical response while EPS emerged at a D 2 receptor occupancy Ͼ 80% (Farde et al. 1992;Nordstrom et al. 1993). This relationship has been confirmed by subsequent clinical studies. In a double-blind PET study with haloperidol, Kapur et al. found that clinical response was manifest at 65-70% D 2 receptor occupancy, but only patients with a D 2 receptor occupancy Ͼ 78% showed signs of EPS (Kapur et al. 2000a).Newly synthesized potentially antipsychotic drugs are tested in the catalepsy (CAT) test (for EPS liability) and the conditioned avoidance response (CAR) test (for

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Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Occupancy Is a Common Mechanism Underlying Animal Models of Antipsychotics and Their Clinical Effects

Wadenberg

Soliman

VanderSpek

et al. 2001

Neuropsychopharmacology

223

167

View full text Add to dashboard Cite

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“…The animals were observed for SB in wire mesh cages (16 Â 30 Â 18 cm) free of water and food. Stereotypy was quantified every 5 min for 150 min after AMP administration according to the scoring system proposed by Setler et al (1976), with some modifications validated in our laboratory for mice. Briefly, scores varying from 0 to 4 were attributed to an animal's behavior by an observer who was unaware of the drug treatment.…”

Section: General Methodsmentioning

confidence: 99%

Characterization of the Rapid-Onset Type of Behavioral Sensitization to Amphetamine in Mice: Role of Drug–Environment Conditioning

Chinen

Faria

Frussa‐Filho

2005

Neuropsychopharmacol

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A rapid-onset type of behavioral sensitization (ROBS) has been demonstrated in rats treated with a single 'priming' injection of amphetamine (AMP). In that species, however, this phenomenon was restricted to AMP-induced stereotyped behavior (SB), not occurring for the locomotor-stimulant effect (LSE) of AMP and not reflecting environment-specific sensitization. In the present study, the ROBS was characterized in the mouse. Mice received a single 'priming' intraperitoneal injection of 5.0 mg/kg AMP which was paired or not with environment. At different intervals (3, 4 or 5 h) subgroups were tested for AMP (1.5 or 5.0 mg/kg)-induced SB or AMP (1.5 mg/kg)-induced open-field LSE. Results showed that: (1) in the absence of drug-environment association, a priming injection of AMP increased the SB induced by a 1.5 mg/kg AMP challenge injection given 3 h (but not 4 or 5 h) later; (2) when the dose of AMP challenge injection was increased to 5.0 mg/kg, an enhancement of SB was verified at all the intervals tested (3, 4, and 5 h); (3) when animals were tested in an open field, the priming injection of AMP produced an increase in the LSE of a 1.5 mg/kg AMP challenge injection, given 4 h later; (4) drug-environment association increased both SB and locomotion after a saline challenge injection and potentiated the rapid-onset sensitization of both behaviors in AMP-challenged mice. Collectively, these results demonstrate that the ROBS phenomenon also occurs in mice, is extended to AMP-induced LSE, and is markedly potentiated by (but does not depend on) environmental conditioning. Neuropsychopharmacology (2006) 31, 151-159.

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“…It is a behavior related to the progressive activation of dopamine receptors of the nigroestriatal pathway. It can be induced by various dopamine agonist drugs such as apomorphine (Setler et al , 1976).…”

Section: Stereotyped Behaviormentioning

confidence: 99%

“…After an eight day isolation period the animals received a subcutaneous dose of 0.6 mg/kg apomorphine hydrochloride (Sigma, Milwaukee, USA). The stereotyped behavior was quantified according to the scoring system proposed by Setler et al (1976) with scores ranging from 0 (asleep or stationary) to 6 (continuous licking and gnawing of cage grids). Observations were made at 10 min intervals for 2 h following apomorphine treatment (observation time not exceeding 10 s per animal).…”

Section: Stereotyped Behaviormentioning

confidence: 99%

Neurobehavioral, reflexological and physical development of Wistar rat offspring exposed to ayahuasca during pregnancy and lactation

Oliveira¹,

Moreira²,

Yonamine³

2011

Rev. bras. farmacogn.

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Ayahuasca is a hallucinogenic beverage prepared by the decoction of plants native to the Amazon Basin region. The beverage has been used throughout the world by members of some syncretic religious movements. Despite the recent legalization of ayahuasca in Brazil for religious purposes, there is little pre-clinical and clinical information attesting to its safety, particularly in relation to the use during pregnancy. The aim of the current work was to determine the effects of perinatal exposure to ayahuasca (from the 6 th day of pregnancy to the 10 th day of lactation) on physical, reflexology and neurobehavioral parameters of the Wistar rat offspring. The offspring showed no statistically significant changes in the physical and reflexology parameters evaluated. However, in adult rats, perinatally exposed to ayahuasca, an increase in frequency of entries in open arms in elevated plus-maze test, a decrease in total time of interaction in social interaction test, a decrease in time of latency for the animal to start swimming and a decrease of the minimum convulsant dose induced by pentylenetetrazol were observed. In conclusion, our results showed that the use of ayahuasca by mothers during pregnancy and lactation reduced the general anxiety and social motivation of the rat offspring. Besides, it promoted a higher sensitivity for initiation and spread of seizure activity.

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Differential attenuation of some effects of haloperidol in rats given scopolamine

Cited by 110 publications

References 18 publications

Dopamine D2 Receptor Occupancy Is a Common Mechanism Underlying Animal Models of Antipsychotics and Their Clinical Effects

Dopamine D2 Receptor Occupancy Is a Common Mechanism Underlying Animal Models of Antipsychotics and Their Clinical Effects

Characterization of the Rapid-Onset Type of Behavioral Sensitization to Amphetamine in Mice: Role of Drug–Environment Conditioning

Neurobehavioral, reflexological and physical development of Wistar rat offspring exposed to ayahuasca during pregnancy and lactation

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