Differential associations between body mass index and outcome in different age groups in patients with myocardial infarction

Kanic, Vojko; Frank, Barbara; Kompara, Gregor; Suran, David

doi:10.1016/j.ihj.2022.06.004

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…For those rest articles, 141 were selected through full-text reading. At last, nine articles satisfying eligibility standards were enrolled in the present meta-analysis [20][21][22][23][24][25][26][27][28].…”

Section: Article Screeningmentioning

confidence: 99%

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Body Mass Index and All-Cause Mortality in Elderly Patients with Percutaneous Coronary Intervention: A Meta-Analysis

Wang,

Li,

Zhang

et al. 2024

Obes Facts

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Background: The ‘obesity paradox’ in elderly patients suffering from percutaneous coronary intervention (PCI) remains a source of controversy. The present meta-analysis focused on exploring the real existence of ‘obesity paradox’ in these patients. Methods: As of November 2022, PubMed, Cochrane and Embase databases were comprehensively searched to identify articles reporting all-cause mortality according to diverse body mass index (BMI) categories after PCI among the old cases developing coronary artery disease (CAD). Summary estimates of risk ratios (RRs) were assigned four BMI groups, including underweight, normal weight, overweight, and obesity groups. Results: There were altogether nine articles involving 25,798 cases selected for further analysis. Relative to normal weight group, overweight and obesity groups had decreased all-cause mortality (RR 0.86, 95%CI 0.77-0.95 for overweight group; RR 0.57,95%CI 0.40-0.80 for obesity group), while underweight group had elevated all-cause mortality (RR 1.52, 95%CI 1.01-2.29). Conclusions: Our study revealed an ‘obesity paradox’ relation of BMI with all-cause mortality in elderly cases receiving PCI. In comparison with normal weight group, overweight and obesity groups had decreased all-cause mortality, while underweight group had increased all-cause mortality.

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Section: Article Screeningmentioning

confidence: 99%

“…Table 1 [20][21][22][23][24][25][26][27][28] displays basic article features. Altogether, nine studies that enrolled 25,798 subjects were included, which were published during 2013-2022.…”

Section: Article Featuresmentioning

confidence: 99%

Body Mass Index and All-Cause Mortality in Elderly Patients with Percutaneous Coronary Intervention: A Meta-Analysis

Wang,

Li,

Zhang

et al. 2024

Obes Facts

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“…Scientists deal with the issues of obesity paradox that indicates reduced mortality rates among high BMI patients following PCI [10]. PCI has the same effect on STEMI patients with or without obesity, and the low risk of side effects in obese patients can not be explained by a lower severity of myocardial infarction [6,11]. Meanwhile, metabolic changes in obese patients with STEMI after PCI remain insufficiently studied to this day.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the post-infarction period in obese patients after percutaneous coronary intervention

Koteliukh¹

2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The study on the metabolic profile in the long-term period after myocardial infarction with comorbidity is relevant. The aim of the work was to examine metabolic profile and echocardiographic parameters in patients with ST-elevation myocardial infarction (STEMI) and obesity following percutaneous coronary intervention (PCI) after a 1-year follow-up. A total of 60 patients with STEMI and obesity were examined. The first subgroup consisted of 20 patients with medicamentous therapy, and the second group – 38 patients with PCI. Adropin, irisin, fatty acid-binding protein 4 (FABP4), C1q/tumor necrosis factor-related protein-3 (CTRP3) were measured by the enzyme-linked immunosorbent assay. The statistical processing of the study results obtained was carried out using the software package “IBM SPPS Statistics 27.0”. The following parameters were increased in patients who received combined medicamentous and PCI therapy before and after the treatment (p<0.05): end-diastolic size (EDS) (by 16.83% and 10.89%, respectively), end-diastolic volume (EDV) (by 45.95% and 18.92% respectively), end-systolic volume (ESV) (by 40.0% and 27.69%, respectively), stroke volume (SV) (by 33.85% and 18.46%, respectively), left ventricular myocardial mass index (LVMMI) (by 18.93% and 10.06%, respectively), adropin (by 27.13% and 47.21%, respectively), irisin (by 2.07 times and 2.75 times, respectively) and CTRP3 (by 15.98 % and 31.96%, respectively), while the following parameters were decreased: systolic blood pressure (by 16.0% and 16.67%, respectively), diastolic blood pressure (by 15.56% and 14.44%, respectively), insulin (by 40 .38% and 48.59%, respectively), glucose (by 10.97% and 15.74%, respectively), atherogenic index (by 6.03% and 12.33%, respectively). Thus, patients with post-infarction cardiosclerosis and obesity have been revealed with increased echocardiographic parameters and imbalanced energy and adipokine metabolism.

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Obesity, ageing and outcomes following myocardial infarction: Additional insights

Jose

Magoon

2022

Indian Heart Journal

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Differential associations between body mass index and outcome in different age groups in patients with myocardial infarction

Cited by 5 publications

References 32 publications

Body Mass Index and All-Cause Mortality in Elderly Patients with Percutaneous Coronary Intervention: A Meta-Analysis

Body Mass Index and All-Cause Mortality in Elderly Patients with Percutaneous Coronary Intervention: A Meta-Analysis

Characteristics of the post-infarction period in obese patients after percutaneous coronary intervention

Obesity, ageing and outcomes following myocardial infarction: Additional insights

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