Differential Association of Serum BDNF With Poststroke Depression and Poststroke Anxiety

Zhengkang, Han; Wang, Yao; Qi, Lili; Wang, Jiening; Wong, John; Chen, Jiaohua; Luo, Xun; Wang, Qing Mei

doi:10.1016/j.apmr.2020.04.011

Cited by 9 publications

(16 citation statements)

References 63 publications

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“…29 Clinical studies have revealed that patients with PSD have a lower level of serum BDNF 30 and ischemic stroke patients with low serum BDNF have a much higher risk for PSD. 31 In this study, PSD rats revealed a significant reduction in serum level of BDNF. Which demonstrated that the animal model of PSD used in this study, at least in part, mimics the actual clinical situation.…”

Section: Discussionmentioning

confidence: 54%

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway

Dong

Qin

Sun

et al. 2021

NDT

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Background Electroacupuncture (EA) is a form of physical therapy that has been widely used in clinical practice in China. Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke. EA has been shown to have beneficial effects on PSD patients. However, the potential mechanism underlying the protective effects of EA on PSD remains unclear. Here, we investigated whether tissue plasminogen activator (tPA)/brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) signaling pathway participates in the therapeutic effects of EA in a rat PSD model. Methods Experimental PSD was induced by combining middle cerebral artery occlusion (MCAO) with chronic unpredictable mild stimulation (CUMS) in adult male rats. Bodyweight gain, neurological score, sucrose preference, and open field test were determined at 0, 7, 14, and 35 days after completing MCAO. The protein expressions of tPA, precursor BDNF (proBDNF), mature BDNF (mBDNF), and TrkB were measured by immunofluorescence and Western blot analysis. The tPA inhibitor plasminogen inhibitor-1 (PAI-1) was used to explore whether tPA plays a crucial role in the protective effects of EA on PSD. Results Compared with the sham rats, the PSD rats showed decreased bodyweight, deteriorated neurological score, and significant depressive-like behaviors. EA remarkably reversed bodyweight loss, neurological deficit, and depressive-like behaviors in PSD rats. Immunofluorescence staining and Western blot analysis showed that PSD-induced decreased expression of tPA, mBDNF, and TrkB were prevented by EA. Furthermore, we found that the effects of EA against PSD-induced depressive-like behaviors were abolished by PAI-1, the specific inhibitor of tPA. Conclusion Our results suggest that the improvement in depressive-like behaviors induced by EA is likely achieved via activation of the tPA/BDNF/TrkB pathway.

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Section: Discussionmentioning

confidence: 54%

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway

Dong

Qin

Sun

et al. 2021

NDT

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“…No significant association between serum levels of mature BDNF and stroke severity was found [ 15 ]. Han et al [ 16 ] studied 162 consecutive stroke patients without any previous history of depression and anxiety and found that a low serum concentration of BDNF was a valuable predictor for the occurrence of PSD. However, using the binary logistic regression model, the odds ratio was only 0.93 (indicating a negative relationship between the categorical and continuous variables), though p = .009.…”

Section: Reviewmentioning

confidence: 99%

“…However, using the binary logistic regression model, the odds ratio was only 0.93 (indicating a negative relationship between the categorical and continuous variables), though p = .009. Further, they determined that the risk of PSD development was much higher in ischemic stroke patients who were divorced or separated and who had lower levels of serum BDNF (p = .002) [ 16 ]. Syafrita et al [ 17 ] studied 72 post-ischemic stroke patients and found that serum BDNF levels in the acute phase of stroke were significantly lower in PSD patients as compared to non-PSD patients (p = .009), with serum BDNF levels significantly negatively correlated with the risk of PSD development (r = - .308) [ 17 ].…”

Section: Reviewmentioning

confidence: 99%

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Brain-Derived Neurotrophic Factor as a Clinical Biomarker in Predicting the Development of Post-Stroke Depression: A Review of Evidence

Shan¹,

Zheng²,

Froud³

2021

Cureus

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Studying the relationship between brain-derived neurotrophic factor (BDNF) and post-stroke depression (PSD) may help determine the potential for depression in stroke patients at the earliest stage possible. Current research has identified changes in BDNF levels in PSD patients. Thus, this article was intended as a review of evidence with respect to changes in the expression of BDNF in patients with PSD by integrating extant findings. We conducted a search in the electronic databases PubMed, EMBASE, and PsycINFO (all records from January 1, 2000, through October 20, 2020) using keywords: “brain-derived neurotrophic factor OR BDNF,” “post-stroke depression OR PSD,” “expression level,” “association,” and “relationship.” Returned articles were considered for inclusion in this review if they were empirical studies investigating the association between BDNF expression and PSD. Seven original papers were selected for review and revealed inconsistent findings. Five out of seven studies reported a significant decrease in BDNF levels in PSD patients at a certain stage (most likely the early stage) of stroke after admission, whereas the other two showed contrasting findings. Overall, this review reveals associations between changes in serum BDNF levels and depression following stroke. Whether serum BDNF levels, especially in the early phase of stroke, can be a potentially effective biomarker for predicting the risk of subsequent PSD development is still open to debate.

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“…After TBI, BDNF levels decrease in both the brain [74] and in the blood, which may predict injury severity [75,76]. Moreover, circulating BDNF levels are decreased in patients with stroke, and especially those patients with post-stroke depression [77] and anxiety [78]. In 2011, Jiang et al successfully administered BDNF into the brains of stroked rats through the IN route.…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

et al. 2020

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This review highlights the pre-clinical and clinical work performed to use intranasal delivery of various compounds from growth factors to stem cells to reduce neuroimmune interactions. We introduce the concept of intranasal (IN) delivery and the variations of this delivery method based on the model used (i.e., rodents, non-human primates, and humans). We summarize the literature available on IN delivery of growth factors, vitamins and metabolites, cytokines, immunosuppressants, exosomes, and lastly stem cells. We focus on the improvement of neuroimmune interactions, such as the activation of resident central nervous system (CNS) immune cells, expression or release of cytokines, and detrimental effects of signaling processes. We highlight common diseases that are linked to dysregulations in neuroimmune interactions, such as Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, and traumatic brain injury.

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Differential Association of Serum BDNF With Poststroke Depression and Poststroke Anxiety

Cited by 9 publications

References 63 publications

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway

Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway

Brain-Derived Neurotrophic Factor as a Clinical Biomarker in Predicting the Development of Post-Stroke Depression: A Review of Evidence

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

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