Differential anti-inflammatory and anti-fibrotic activity of transplanted mesenchymal vs. hematopoietic stem cells in carbon tetrachloride-induced liver injury in mice

Sivasami, Pulavendran; Jayarajan, Vignesh; Rose, C.

doi:10.1016/j.intimp.2010.01.014

Cited by 58 publications

(46 citation statements)

References 34 publications

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“…The lack of scarification in the MSC-seeded scaffolds and the subsequent robust muscle growth may be attributed to the fact that MSCs can act as immune modulators. In a variety of different systems, MSCs have been shown to possess immunomodulatory characteristics including an abrogation in proinflammatory cytokines [43][44][45]. The grafts in our model may have benefited from the protective mechanism brought forth by the bMSCs.…”

Section: Discussionmentioning

confidence: 92%

A Nonhuman Primate Model for Urinary Bladder Regeneration Using Autologous Sources of Bone Marrow-Derived Mesenchymal Stem Cells

et al. 2011

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Animal models that have been used to examine the regenerative capacity of cell-seeded scaffolds in a urinary bladder augmentation model have ultimately translated poorly in the clinical setting. This may be due to a number of factors including cell types used for regeneration and anatomical/ physiological differences between lower primate species and their human counterparts. We postulated that mesenchymal stem cells (MSCs) could provide a cell source for partial bladder regeneration in a newly described nonhuman primate bladder (baboon) augmentation model. Cell-sorted2 baboon MSCs transduced with green fluorescent protein (GFP) were seeded onto small intestinal submucosa (SIS) scaffolds. Baboons underwent an approximate 40%-50% cystectomy followed by augmentation cystoplasty with the aforementioned scaffolds or controls and finally enveloped with omentum. Bladders from sham, unseeded SIS, and MSC/SIS scaffolds were subjected to trichrome, H&E, and immunofluorescent staining 10 weeks postaugmentation. Immunofluorescence staining for muscle markers combined with an anti-GFP antibody revealed that >90% of the cells were GFP Disclosure of potential conflicts of interest is found at the end of this article.

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Section: Discussionmentioning

confidence: 92%

A Nonhuman Primate Model for Urinary Bladder Regeneration Using Autologous Sources of Bone Marrow-Derived Mesenchymal Stem Cells

et al. 2011

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“…These data indirectly indicate that the effectiveness of MSCs is better than that of blood stem cells. A direct comparison of immune-modulating efficacy between MSCs and hematopoietic stem cells (HSCs) in an animal model of liver injury demonstrated that MSCs are more competent than HSCs in alleviating the immunoreaction-related fibrosis in the liver (Pulavendran et al 2010). Thus, transplantation of MSCs should be considered as a major treatment option for inflammatory neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonography-guided transplantation facilitates perineural delivery of stem cells

Kim

Joo

Hong

et al. 2015

Animal Cells and Systems

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Treatment options for peripheral neuropathy are very limited. In order to develop a therapeutic strategy using stem cell therapy for the peripheral nervous system, we explored the feasibility of a new delivery method. Using ultrasonographyguided transplantation, human mesenchymal stem cells (hMSCs) were delivered into the perineural region of small rodent models. An optical imaging system revealed that hMSCs stained with CFSE or PKH26 reside for a week posttransplantation in both the mouse and rat. Immunofluorescence analysis of tissues revealed the presence of transplanted hMSCs in the perineural region of mice. At the end of the experiments, no behavioral or phenotypic abnormalities were observed. In addition, H&E and toluidine blue staining showed the integrity of the sciatic nerve after transplantation. This is the first study, to the best of our knowledge, to deliver cells into the perineural region under ultrasonography guidance. Since hMSCs can reside for a considerable time at a transplanted site, an anti-inflammatory efficacy of the transplanted hMSCs can be expected in the perineural region. In conclusion, we established a new administration route for inflammatory peripheral neuropathy without complications, and this may be used for delivery of chemical drugs or stem cells.

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“…IL1Ra, secreted by the MSCs, was found to be integral to this process and acted by blocking tumor necrosis factor (TNF)-a and IL-1 in the lung (Ortiz et al, 2007). An immunosuppressive mechanism of action for MSCs was also demonstrated in carbon tetrachloride-induced liver injury resulting in suppressed fibrosis, an effect specific for MSCs as administration of hematopoietic stem cells resulted in acute inflammation and subsequent fibrosis (Pulavendran et al, 2010).…”

Section: Paracrine Effectsmentioning

confidence: 99%

Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?

et al. 2010

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Differential anti-inflammatory and anti-fibrotic activity of transplanted mesenchymal vs. hematopoietic stem cells in carbon tetrachloride-induced liver injury in mice

Cited by 58 publications

References 34 publications

A Nonhuman Primate Model for Urinary Bladder Regeneration Using Autologous Sources of Bone Marrow-Derived Mesenchymal Stem Cells

A Nonhuman Primate Model for Urinary Bladder Regeneration Using Autologous Sources of Bone Marrow-Derived Mesenchymal Stem Cells

Ultrasonography-guided transplantation facilitates perineural delivery of stem cells

Mesenchymal Stem Cells and Osteoarthritis: Remedy or Accomplice?

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