Differential AMPK-mediated metabolic regulation observed in hibernation-style polymorphisms in Siberian chipmunks
Taito Kamata,
Shintaro Yamada,
Tsuneo Sekijima
Abstract:Hibernation is a unique physiological phenomenon allowing extreme hypothermia in endothermic mammals. Hypometabolism and hypothermia tolerance in hibernating animals have been investigated with particular interest; recently, studies of cultured cells and manipulation of the nervous system have made it possible to reproduce physiological states related to hypothermia induction. However, much remains unknown about the periodic regulation of hibernation. In particular, the physiological mechanisms facilitating th… Show more
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