Differential Alternative Splicing Landscape Identifies Potentially Functional RNA Binding Proteins in Early Embryonic Development in Mammals

mRNA isoform switches during mouse zygotic genome activation

“…To date, several studies have reported the differences in mRNA isoforms expressed before and after ZGA by using normal fertilized embryos. [19][20][21][22] However, whether paternal or maternal genomes generate specific patterns of mRNA isoforms during mammalian ZGA has not been reported. A systematical depiction of the mRNA isoform patterns during ZGA and between parental genomes will provide vital insights into how sperm and oocyte genomes regulate complicated mammalian development.…”