Differential alterations of tissue T-cell subsets after sepsis

Sharma, Archna; Yang, Weng Lang; Matsuo, Shingo; Wang, Haichao

doi:10.1016/j.imlet.2015.09.005

Cited by 46 publications

(42 citation statements)

References 60 publications

(61 reference statements)

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“…CD4 + CD25 + Tregs are modulator of adaptive and innate immune responses (Bakır et al, 2016;Kanakasabai et al, 2012). Some cytokines prevent the immune system, for example, transforming growth factor-beta (TGF-β) and IL-10 produced by Tregs, which play an important role in tolerating the immune system in sepsis (Chen, Zhou, Shan, Li, & Lin, 2015;Sharma, Yang, Matsuo, & Wang, 2015).…”

Section: Immunomodulatory Effect Of Curcumin On T Cellmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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Section: Immunomodulatory Effect Of Curcumin On T Cellmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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“…73,91,104,107 Similar to naive T cells, numerical alterations of memory T cells are driven by sepsis-induced apoptosis, which is facilitated by cell expression of LFA-1 (CD11a). 73,91,108 Reductions in the quantity of memory T cells suggest a mechanism for septic patients enhanced susceptibility to previously encountered pathogens.…”

Section: Role Of Sepsis In Shaping Infection And/or Vaccine-inducementioning

confidence: 99%

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity

et al. 2016

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Septic patients experience chronic immunosuppression resulting in enhanced susceptibility to infections normally controlled by T cells. Clinical research on septic patients has shown increased apoptosis and reduced total numbers of CD4 and CD8 T cells, suggesting contributing mechanism driving immunosuppression. Experimental models of sepsis, including cecal ligation and puncture, reverse translated this clinical observation to facilitate hypothesis-driven research and allow the use of an array of experimental tools to probe the impact of sepsis on T-cell immunity. In addition to numerical loss, sepsis functionally impairs the antigen-driven proliferative capacity and effector functions of CD4 and CD8 T cells. Sepsis-induced impairments in both the quantity and quality of T cells results in reduced protective capacity and increased susceptibility of mice to new or previously encountered infections. Therefore, the combined efforts of clinical and experimental sepsis research have begun to elucidate the impact of sepsis on T-cell-mediated immunity and potential T-cell-intrinsic and -extrinsic mechanisms driving chronic immunosuppression. Future work will explore the impact of sepsis on the recently appreciated tissue-resident memory (TRM) T cells, which provide robust protection against localized infections, and dendritic cells, which are needed to activate T cells and promote effective T-cell responses.

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“…It is well known that CD4 + T cells are heavily impacted during sepsis, in that both human septic patients and experimental mouse models of sepsis demonstrate profound CD4 + T cell apoptosis and loss of functionality (2, 5). Importantly, preventing CD4 + T cell apoptosis has been shown to reverse sepsis-induced mortality in mouse models.…”

Section: Introductionmentioning

confidence: 99%

Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis

Chen

Mittal

Klingensmith

et al. 2017

The Journal of Immunology

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Sepsis is a leading cause of death in the U.S. but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memory CD8+ T cells that has been shown to regulate T cell function in models of viral infection and autoimmunity. Here we show that 2B4 signaling mediates sepsis lymphocyte dysfunction and mortality. 2B4 expression is increased on CD4+ T cells in both septic animals and human patients at early time points. Importantly, genetic loss or pharmacologic inhibition of 2B4 each significantly increased survival in a murine cecal ligation and puncture (CLP) model. Further, CD4-specific conditional knockouts showed that 2B4 functions on CD4+ T cell populations in a cell-intrinsic manner and modulates both adaptive and innate immune responses during sepsis. Our results illuminate a novel role for 2B4 coinhibitory signaling on CD4+ T cells in mediating immune dysregulation.

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Differential alterations of tissue T-cell subsets after sepsis

Cited by 46 publications

References 60 publications

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity

Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis

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