Differential allergy responses toMetarhizium anisopliaefungal component extracts in BALB/c mice

Influence of Consumption of Two Peruvian Cocoa Populations on Mucosal and Systemic Immune Response in an Allergic Asthma Rat Model

“…In our study, no changes in BALF IgA content in asthmatic animals were found. These results agree with data reported in a mouse model of allergic asthma also induced with OVA [ 51 ], however, they do not concur with another study in mice with allergic asthma induced using a fungal biopesticide showing an IgA increase [ 52 ]. Although the BALF IgA content was not influenced by allergy asthma induction in our model, the OC and CMC diets—but not the APC diet—decreased it.…”

The effects of pregnancy on the exacerbation and development of maternal allergic respiratory disease

“…BALF IgE concentrations did not differ appreciably (data not shown). It must be noted that all of the IgE levels were considerably lower than those usually obtained following similar exposure protocols in our laboratory (Ward et al, 2009), despite the otherwise robust inflammatory response. The reason for this discrepancy is unknown, but may reflect batch-dependent differences in IgE-inducing allergen components.…”

Allergic Responses Induced by a Fungal BiopesticideMetarhizium anisopliaeand House Dust Mite Are Compared in a Mouse Model

“…One agent Bacillius thuringiensis , in use for many years, has been shown to induce IgE responses from occupational exposures [63, 64]. Additionally, there are both human and animal studies indicating that M. anisopliae exposure may induce allergy and possibly asthma [32, 33, 35]. Although the data in this report suggests that M. anisopliae is a robust allergen source, this is not the case for all molds or fungal biopesticides.…”

“…Previous studies in our laboratory [32, 33, 39] have found that M. anisopliae extract has the capacity to induce allergic responses in a mouse model. In the present study, the relative allergenicity of the biopesticide M. anisopliae was compared to HDM induced responses based on various endpoints with an emphasis on those that are characteristic of human allergic responses, for example, serum total and antigen-specific IgE and inflammatory cell (neutrophils and eosinophils) influx into the lungs (summarized in Table 1).…”

“…Thus suggesting that in some instances humans and other mammals may be susceptible to M. anisopliae infection. Previous studies in our laboratory [32, 33] have demonstrated that multiple respiratory exposures to M. anisopliae extract can elicit inflammatory and respiratory physiological responses characteristic of human allergic asthma in BALB/c mice. Furthermore, anecdotal information as well as limited clinical data has suggested that some individuals exposed occupationally to M. anisopliae have become sensitized [34].…”